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Drug Metabolism and Disposition Highlighted Trainee Author, August 2021

August 02, 2021

Parvez MasudMasud Parvez is the Drug Metabolism and Disposition Highlighted Trainee Author for the August 2021 issue.  Dr. Parvez is a postdoctoral trainee in the Department of Pharmaceutical Sciences at the Washington State University.  His mentor is Dr. Bhagwat Prasad.  He earned a Ph.D. in pharmacology from Inje University, South Korea. The DMD article that earned his selection as a Highlighted Trainee Author is titled “Quantitative Investigation of Irinotecan Metabolism, Transport, and Gut Microbiome Activation” and is available at https://doi.org/10.1124/dmd.121.000476.

Dr. Parvez’s area of research is understanding the impact of an interplay between drug transporters and metabolic enzymes on drug disposition, pharmacokinetic drug-drug interactions, and in vitro to in vivo extrapolations. His current work is focused on characterizing the individual contributions of drug transporters and enzymes to the disposition of a drug and metabolites, to understand tissue disposition mechanisms. He utilizes proteomics-informed in vitro to in vivo extrapolations (IVIVE) to predict tissue drug/metabolite exposure and their anticipated clinical impact. His work also includes identifying an ontogeny profile of the drug-metabolizing enzyme and transporter protein abundances among the pediatric population and developing a physiologically based pharmacokinetic model to understand developmental and interindividual pharmacokinetic variability.

The anticipated impact of Dr. Parvez’s current research is a better understanding of the interindividual pharmacokinetic variability, drug-drug interactions, and drug toxicity in the clinics.  In a broader sense, the IVIVE model based early tissue exposure prediction will be greatly helpful in the drug developmental process specifically in the first-in-human clinical study design.

When not in the lab, Masud enjoys traveling, reading, and playing.

 

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Last Updated: November 11, 2021

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