Pasquale Mone is the Journal of Pharmacology and Experimental Therapeutics Highlighted Trainee Author for the June 2022 issue. He is a PhD Student in clinical and experimental medical sciences at Campania University and at the Department of Medicine at Albert Einstein College of Medicine, under the mentorship of Prof. Gaetano Santulli. The JPET article that earned his selection as a Highlighted Trainee Author is titled “L-Arginine Enhances the Effects of Cardiac Rehabilitation on Physical Performance: New Insights for Managing Cardiovascular Patients During the COVID-19 Pandemic” and is available at https://doi.org/10.1124/jpet.122.001149.
Mr. Mone’s doctoral work focuses on understanding the mechanisms underlying endothelial dysfunction in frailty. During his training in the Santulli Lab, he expanded his scientific skills and technical capabilities to investigate the pathophysiology of cardiovascular and metabolic disorders. This work has earned him several first-author peer-reviewed publications.
The current emphasis of Mr. Mone’s work is on signaling pathways involved in the pathogenesis of coronary artery disease and cognitive impairment, including non-coding RNAs. He utilizes top-notch techniques to analyze signaling in living cells, as well as ex vivo and in vitro assays to measure various key processes in different cell types, with the ultimate goal of translating his results to the clinical scenario.
The anticipated impact of Mr. Mone’s current research is that identifying and targeting new molecular targets in frailty could lead to novel effective therapeutics.
When not in the lab, Pasquale enjoys music, art, and traveling.