A special section entitled “Nanotechnology-based Delivery Strategies for Protein and Peptide Therapeutics” is expected to be published in the January 2024 issue of The Journal of Pharmacology and Experimental Therapeutics.
Protein and peptide therapeutics promise significant clinical advantages in severe disorders such as cancer, diabetes, multiple sclerosis, and autoimmune diseases. Their higher potency, greater specificity, and fewer immunological responses all account for these advantages. However, protein and peptide therapeutics also have delivery challenges due to their low oral bioavailability, low plasma stability, short circulation time in the biological milieu, immunogenicity, and inability to cross cell membranes.
This special section is a call for original research as well as authoritative reviews focused on varied nanotechnology-driven delivery approaches for protein and peptide-based therapeutics.
Prospective articles can include:
- Nanocarrier-based delivery strategies
- PEGylation of protein and peptides
- Hydrophobization
- Encapsulation/Electrostatic interaction
- Self-assembly via electrostatic interactions
- Hydrogen bonding
- Hydrophobic interactions
- Polymerization-based encapsulation
- Co-delivery with permeation enhancers or protease inhibitors and active targeting by ligand/antibody/peptide conjugation for site-specific delivery
Full-length articles focusing on, but not limited to, the above-mentioned aspects of protein and peptide delivery will be considered. Please send a presubmission inquiry including title, author information, abstract, and significance statement to The Journal of Pharmacology and Experimental Therapeutics prior to full submission.
The guest editors, Prof. Anupama Mittal and Prof. Deepak Chitkara, will review these presubmission inquiries, respond to the authors with comments, and assess whether final approval will be granted for a full submission. All submissions to the journal must refer to the journal’s Instructions to Authors before submission of articles. The full paper submission deadline is March 2023.