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4th GPCR Colloquium

Boston Convention & Exhibition Center, Room 157ABC.

Posters will be located in Room 156ABC

A satellite program to the joint ASPET/BPS Annual Meeting at EB 2013

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Sponsored by the ASPET Divisions for Neuropharmacology, Molecular Pharmacology, Drug Discovery and Development, & Toxicology, and the British Pharmacological Society 

Laura Bohn, PhD, The Scripps Research Institute, Scripps Florida
Roger Sunahara, PhD, University of Michigan Medical School
Graeme Milligan, PhD, University of Glasgow, College of Medical, Veterinary and Life Sciences


To register for the meeting:

ASPET Members, login to the Members Only section to register.

Nonmembers, please register here.

BPS Members can register for the Colloquium at Member rates. Please click here to register (login required).

Online registration will close Tuesday, April 16, at 5:00 p.m. EDT. Registration will be available on site.



Wednesday, April 24:
1:00 PM
Registration open

2:00 PM – 2:05 PM
Welcome and introduction to the 4th GPCR Colloquium and Sir James Black Honorary Lecture

2:05 PM – 2:55 PM
Sir James Black Honorary Lecture
Molecular mechanisms of biased agonism at 7 transmembrane receptors
Robert J. Lefkowitz, Duke University

[3:00 PM – 5:30 PM]
Bridging the efficacy divide:  Novel molecular insights driving biased ligand drug discovery
Jointly sponsored by the Divisions of Molecular Pharmacology and Neuropharmacology
Session Chairs: Arthur Christopoulos and Robert J. Lefkowitz

3:00 PM – 3:35 PM
Biased ligands: Developing better drugs through selective signaling at GPCRs
Jonathan Violin, Trevena, Inc.

3:35 PM – 4:10 PM
Ligand-biased signaling under the light of BRET
Michel Bouvier, Université de Montréal

4:10 PM – 4:45 PM
Allosteric modulation of endogenous metabolites: Implications for on- and off-target drug action and bias
Patrick M. Sexton, Monash University

4:45 PM – 5:20 PM
Moving from biased signaling to functional (physiological) bias
Andrew Tobin, University of Leicester

5:20 PM – 5:30 PM
The atypical antipsychotic clozapine induces 5-HT2AR-mediated signaling and behavioral events in a beta-arrestin2-independent but Akt-dependent manner
Junior Speaker: Cullen Schmid, The Scripps Res. Inst.

Official end of ASPET’s Annual Meeting at Experimental Biology 2013.
Attendance at the poster sessions, dinner and remainder of the Colloquium on Wednesday evening and Thursday requires separate registration.
(See registration links above.)

5:30 PM – 8:30 PM
Open Registration; POSTER PRESENTATIONS; DINNER (Buffet- 6:30pm) for GPCR symposium (Poster awards if prizes can be raised; Sponsorship needed, Please contact Christie Carrico or Laura Bohn).

Thursday, April 25:
8:00 AM – 8:30 AM
Registration Open, Coffee

8:30 AM – 9:20 AM
Allosteric modulators: Enhancing the selectivity and potency of current therapeutics
Allosteric modulators for improving CNS therapeutic targets
Jeff Conn, Vanderbilt University

[9:25 AM – 11:05 AM]
Report from the MLPCN GPCR probe development
Session Chair: Laura Bohn

9:25 AM – 10:05 AM
Introduction to the MLPCN and an update on Sphingosine1Phosphate receptor drug development
Hugh Rosen, The Scripps Research Institute

10:10 AM – 10:35 AM
The chemistry behind CNS drug development
Jeff Aubé, University of Kansas

10:40 AM – 11:05 AM
An industry perspective on GPCR drug discovery
Chris Felder, Eli Lilly and Company

11:05 AM – 11:20 AM

[11:20 AM – 12:20 PM & 1:30 PM – 1:55 PM]
Location, location, location: Diverse signaling  as a function of context (within the cell)

11:20 AM – 11:55 AM
Receptor trafficking determining receptor signaling
Mark von Zastrow, University of California, San Francisco

11:55 AM – 12:20 PM
Signaling from the nuclear membrane: Metabotropic glutamate receptor, mGluR5, triggers unique signaling cascades from inside the cell
Karen O’Malley, Washington University

12:20 PM – 1:30 PM
LUNCH: Provided

[1:30 PM – 3:00 PM]
Structure and function: Emphasis on context and drug design
Session Chair: Roger Sunahara

1:30 PM – 2:10 PM
An update on GPCR structure and drug development
Roger Sunahara, University of Michigan Medical School

2:15 PM – 2:40 PM
X-ray Structures for the predictive generation of GPCR drugs
Fiona Marshall, Heptares Therapeutics

2:45 PM – 3:05 PM
Cannabinoid ligands gaining entry
Patricia Reggio, University of North Carolina, Greensboro

[3:10 PM – 4:40 PM]
Transient or transformative: Receptor oligomerization finds its way

3:10 PM – 3:40 PM
The prevalence, maintenance and relevance of GPCR oligomerization
Graeme Milligan, University of Glasgow

3:45 PM – 4:10 PM
5HT2AR-mGluR interactions and implications in schizophrenia
Javier González-Maeso, Mount Sinai School of Medicine

4:10 PM

Corporate Sponsors include: 


Sponsorship Opportunities for the 4th GPCR Colloquium  

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