In This Section

Division for Drug Metabolism and Disposition Okita Early Career Award Lecture, Gillette Award Lectures, and Junior Investigator Platform Session

Friday April 30, 2021

2:00 pm - 4:00 pm Central Time (CT)

View session on the EB Virtual Platform (EB registration required)

DMDD

Chair :

Robert Foti
Merck

Xiao-bo Zhong
Univ of Connecticut

This session features a lecture given by the recipient of the 2021 Richard Okita Early Career Award in Drug Metabolism and Disposition, talks from the authors of the best papers of 2020 from the journal Drug Metabolism and Disposition who received the James R. Gillette Award, as well as abstract-based oral presentations focused on drug metabolism and disposition.

Speakers

Huichang Bi - Sun Yat-sen University and Southern Medical University

Nuclear Receptors in Hepatomegaly and Liver Regeneration: An Update

This presentation updates the activation of pregnane X receptor (PXR), peroxisome proliferator-activated receptor-α (PPARα) and constitutive androstane receptor (CAR) on hepatomegaly and liver regeneration. Mechanistically, the interactions between these nuclear receptors and yes-associated protein (YAP) signals were presented and discussed.

Shujuan Chen - Univ. of California, San Diego

Differential Role of Liver X Receptor (LXR) α and LXRβ in the Regulation of UDP-Glucuronosyltransferase 1A1 in Humanized UGT1 Mice

Bridget Morse - Eli Lilly and Company

Pharmacokinetics of Organic Cation Transporter 1 (OCT1) Substrates in Oct1/2 Knockout Mice and Species Difference in Hepatic OCT1-Mediated Uptake

Eric Mosher - Johns Hopkins University School of Medicine

Naturally-Occurring Mutations to Muscle-Type Creatine Kinase Differentially Impact Canonical and Pharmacological Activities in Vitro

Aratrika Saha - LSUHSC

Role of the Proximal Region of CYP1A2 in the Homomeric P450 Complex Formation

Ankit Balhara - National Institute of Pharmaceutical Education and Research (NIPER), SAS Nagar

Comparative Proteomics Analysis of the Post-Mitochondrial Fraction (S9 Fraction) of Human Lens-Free Whole Eye and Liver

Austin Sun - University of Washington

Evaluation of Large Organic Anion Transport at the Blood-CSF Barrier by Quantitative Fluorescence Microscopy