In This Section

Ectopically Expressed Olfactory Receptors: Promises and Challenges of the Understudied GPCR Family

Tuesday April 05, 2022

8:00 am - 9:30 am Eastern Time (ET)



CVP DDD MP

Chair :

Vladlen Slepak
University of Miami

Jennifer Pluznick
Johns Hopkins University



G protein-coupled receptors (GPCRs) are the arguably the most important drug target. About 50% of the ~800 GPCRs belong to the families of olfactory and taste receptors. While they were originally cloned from sensory organs, in the past decade expression of these genes was discovered in many other tissues. Technical difficulties with functional expression of these receptors in vitro and unavailability of tools for their analysis impeded progress in this field for many years. This session will highlight recent advances facilitating investigations of these understudied GPCRs and insights into their physiological functions, pharmacology and potential role in human disease.

Speakers

Blythe Shepard - Georgetown University

Emerging Roles for Olfactory Receptors in Glucose Homeostasis and Metabolism

Olfactory receptors (OR) are found in a variety of metabolically-active tissues including the kidney and liver. Our work thus far has focused on the role(s) that these receptors play in both glucose homeostasis and metabolism. This talk will focus on the pharmacological characterization of these receptors as well as their emerging physiological functions.

Jennifer Pluznick - Johns Hopkins University

The Role of Smell Receptors in the Kidney

In the mouse, olfactory receptor Olfr78 is expressed in several tissues including the blood vessels of the kidney. Our mouse genetics and physiological studies demonstrated that these receptors regulate blood pressure by responding to short chain fatty acids produced by gut microbiome. This talk will provide an update on this research, focusing on pharmacological characterization of Olfr78 and related receptors.

Alexey Pronin - University of Miami School of Medicine

Targeting Prostate Cancer Cells via Ectopically Expressed Olfactory Receptors OR51E1/2

To enable the discovery of novel OR ligands, we developed a robust HTS-ready system for expression and analysis of functional ORs in stable cell lines. Our focus is on OR51E1 and OR51E2, which are well established markers for human prostate cancer. Our studies revealed ligand specificity and cytostatic and cytotoxic activity of these receptors.

Talks will be selected from submitted abstracts.

Last Updated: August 31, 2021
Key Dates
 
November 30, 2021

Abstract Submission Deadline

February 7, 2022

Early Registration Deadline

April 2 – 5, 2022

ASPET Annual Meeting at EB 2022

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