FR900359: Nature’s Weapon and Treasure Trove for Basic and Translational Research
Natural products have been a rich source of compounds for basic research and drug discovery. One such example is FR900359, a highly selective inhibitor of Gq family proteins. Along with the structurally close analog YM254890, both molecules offer the exciting perspective to interfere with Gq-dependent signaling in health and disease: in health to understand Gq contribution to complex signaling networks, in disease to treat pathologies caused by overactivity of Gq proteins. Dr. Kostenis, a leader in the use of depsipeptides to target Gq, will provide an update on her research in this area.