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DMD Virtual Special Sections

Virtual Special Section (VSS) on “Drug metabolism by the gut microbiota”

VSS Editor:  Young Jeong, Virtual Special Section Editor
Submission Deadline: December 31, 2024

DMD invites original research articles and mini reviews on topics related to drug metabolism by the gut microbiota. These include but are not limited to: studies on the identification/characterization of novel biotransformation reactions or drug metabolism by microbes and their impact on drug therapy; absorption/distribution/metabolism/excretion studies of drugs that undergo gut microbial metabolism. Mini reviews on current research advances and perspectives on the relevant research are also encouraged.

 

Virtual Special Section (VSS) on “Endogenous biomarkers of drug-metabolizing enzymes and transporters”

VSS Editor: Yurong Lai
Submission Deadline: March 31, 2025

DMD invites original research articles and mini-reviews on topics related to the endogenous biomarkers of drug-metabolizing enzymes or transporters. These include (not limited to) studies on the identification, translation and verification of endogenous biomarkers (e.g., metabolites, genetic polymorphisms or organ impairment) to assess drug disposition or drug-drug interactions. We also welcome mini-reviews on current perspectives on relevant topics. Manuscripts will be reviewed as they are submitted. Accepted papers will be published in a regular DMD issue and archived here in the Special collection as a Virtual Special Issue.

 

Virtual Special Section (VSS) on “Novel Animal Models”

VSS Editor:Hiroshi Yamazaki
Submission Deadline: April 30, 2025

DMD invites original research, Mini-Reviews, and perspectives on topics related to novel animal models for predicting drug metabolism and toxicity in human patients and animal species under veterinary care for a new Virtual Special Section. Accepted papers will be published in a regular DMD issue and archived here in the Special collection as a Virtual Special Issue.

 

Virtual Special Section (VSS) on “Sex and hormonal influences on drug metabolism and disposition, and related studies”

VSS Editor:David Riddick
Submission Deadline: April 30, 2025

DMD invites original research articles and minireviews on topics related to sex differences in or hormonal regulation of any aspects of drug metabolism, drug transport or drug disposition. Mechanistic studies of the metabolism, transport or disposition of endogenous hormones or exogenous endocrine-disrupting chemicals are also welcomed. Consideration will be given to studies including, but not limited to, in vitro systems, animal models and clinical investigations.

 

Manuscripts will be reviewed as they are submitted. Accepted papers will be published in a regular DMD issue and archived here in the special collection as a Virtual Special Section Issue. Virtual Special Section content will be freely available for six months after acceptance.

For questions about submitting a manuscript to this Virtual Special Section, contact DMD@aspet.org.

 

Drug metabolism by the gut microbiota

  1. Gut Microbiome Integration in Drug Discovery and Development of Small Molecules

  2. Patrick Jimonet, Céline Druart, Stephanie Blanquet-Diot, Lilia Boucinha, stephanie Kourula, Françoise Le Vacon, Sylvie Maubant, Sylvie Rabot, Tom Van de Wiele, Frank Schuren, Vincent Thomas, Bernard Walther and Michael Zimmermann

 

Endogenous biomarkers of drug-metabolizing enzymes and transporters

  1. Effect of Cimetidine on Metformin Pharmacokinetics and Endogenous Metabolite Levels in Rats

    Anoud Sameer Ailabouni, Vijaya Saradhi Mettu, Aarzoo Thakur, Dilip Kumar Singh and Bhagwat Prasad

  2. Assessing Pleiotropic Effects of a Mixed-Mode Perpetrator Drug, Rifampicin, by Multiple Endogenous Biomarkers in Dogs

    Renmeng Liu, Bin Ma, Marilyn M. Mok, Bernard P. Murray, Raju Subramanian and Yurong Lai

 

Novel Animal Models

  1. Novel Cytochrome P450 2C119 Enzymes in Cynomolgus and Rhesus Macaques Metabolize Progesterone, Diclofenac, and Omeprazole

    Yasuhiro Uno, Norie Murayama and Hiroshi Yamazaki

  2. Novel Tree Shrew Cytochrome P450 2Ds (CYP2D8a and CYP2D8b) Are Functional Drug-Metabolizing Enzymes that Metabolize Bufuralol and Dextromethorphan

    Genki Ushirozako, Norie Murayama, Kyoko Tsukiyama-Kohara, Hiroshi Yamazaki and Yasuhiro Uno

  3. Pharmacokinetic Models Scaled Up from Humanized Liver Mouse Data Can Account for Drug Monitoring Results of Atomoxetine and Its 4-Hydroxylated and N-Demethylated Metabolites in Pediatric Patients Genotyped for Cytochrome P450 2D6

    Makiko Shimizu, Shotaro Uehara, Katsuhiro Ohyama, Haruka Nishimura, Yoichi Tanaka, Yoshiro Saito, Hiroshi Suemizu, Sayaka Yoshida and Hiroshi Yamazaki

  4. Pharmacokinetic Effects of Different Models of Nonalcoholic Fatty Liver Disease in Transgenic Humanized OATP1B Mice

    Baron J Bechtold, Katherine D Lynch, Victoria O Oyanna, M Ridge Call, Laura A White, Tyler N Graf, Nicholas H. Oberlies and John D. Clarke

 

Sex and hormonal influences on drug metabolism and disposition, and related studies

  1. Activation of the YY1-UGT2B7 axis promotes mammary estrogen homeostasis dysregulation and exacerbates breast tumor metastasis

    Jiahao Xu, Ying Zhou, Shiqing He, Yinghao Wang, Jiachen Ma, Changwen Li, Zhao Liu and Xueyan Zhou

 

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