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Adhesion GPCRs as Neurotherapeutic Targets

Sunday April 22, 2018

3:30 pm - 6:00 pm

Room 16A
Sponsored by the Division for Molecular Pharmacology (MP)
Co-sponsored by the Division for Behavioral Pharmacology (BEH)
Co-sponsored by the Division for Drug Discovery and Development (DDD)
Co-sponsored by the Division for Translational and Clinical Pharmacology (TCP)

Chair :

Xianhua Piao
Harvard University

Gregory Tall
University of Michigan


Adhesion GPCRs (AGPCRs) are critical regulators of nervous system development and physiology. Most AGPCRs are considered understudied by the NIH, yet they comprise ~10% of all non-sensory GPCRs. Rapid developments have ensued including elucidation of a common activation mechanism, recognition that AGPCRs control glial progenitor differentiation and nerve myelination, and act as trans-synaptic connectors. The potential of AGPCRs as therapeutic targets has gained traction through discovery of small molecule receptor modulators. The symposium brings together a collection of experts in different facets of AGPCR neurobiology who will present cutting edge topics.

GPR56 Regulation of Glial Cell Development
Xianhua Piao - Harvard University

Structural and Functional Studies of Adhesion GPCRs
Demet Arac - University of Chicago

BAI Regulation of Synaptic Function and Involvement in Neurological Disease
Randy Hall - Emory University

New Probe Compounds to Investigate Adhesion GPCR Activation Mechanisms
Gregory Tall - University of Michigan

Adhesion-GPCR Function in Synapses
Thomas Sudhof - Stanford University School of Medicine

Thank you to our Annual Meeting partners:

Amgen
University of Florida
Wake Forest University
Washington State University College of Pharmacy and Pharmaceutical Sciences
University of Wisconsin Molecular and Cellular Pharmacology Training Program
UT Health San Antonio
University of Minnesota

Emory University Pharmacology

PR & P
University of Michigan Medical School Pharmacology
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