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Adhesion GPCRs as Neurotherapeutic Targets

Sunday April 22, 2018

3:30 pm - 6:00 pm Eastern Time (ET)

Room 16A


Chair :

Xianhua Piao
Harvard University

Gregory Tall
University of Michigan

Adhesion GPCRs (AGPCRs) are critical regulators of nervous system development and physiology. Most AGPCRs are considered understudied by the NIH, yet they comprise ~10% of all non-sensory GPCRs. Rapid developments have ensued including elucidation of a common activation mechanism, recognition that AGPCRs control glial progenitor differentiation and nerve myelination, and act as trans-synaptic connectors. The potential of AGPCRs as therapeutic targets has gained traction through discovery of small molecule receptor modulators. The symposium brings together a collection of experts in different facets of AGPCR neurobiology who will present cutting edge topics.


Xianhua Piao - Harvard University

GPR56 Regulation of Glial Cell Development

Demet Arac - University of Chicago

Structural and Functional Studies of Adhesion GPCRs

Randy Hall - Emory University

BAI Regulation of Synaptic Function and Involvement in Neurological Disease

Gregory Tall - University of Michigan

New Probe Compounds to Investigate Adhesion GPCR Activation Mechanisms

Thomas Sudhof - Stanford University School of Medicine

Adhesion-GPCR Function in Synapses