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ASPET Presidential Symposium: Deadly Liaisons: Squeezing the Life Out of Cancer

Sunday April 22, 2018

9:30 am - 12:00 pm Eastern Time (ET)

Room 16A


Chair :

John Schuetz
St. Jude Children's Research Hospital

Mary-Ann Bjornsti
University of Alabama-Birmingham

Recent scientific advances have brought significant progress in cancer treatment, but also reveal the challenges and complexities of pharmacologically targeting cancer. These advances extend from genomics, to chemical biology, to acquiring knowledge of the unique susceptibilities of individual cancers that drive drug discovery. This symposium provides a state-of-the art overview of Cancer Pharmacology by international leaders in their respective fields. Topics include: using genomics to elucidate the determinants of anticancer drug toxicity and efficacy; discovering druggable pathways in novel, clinically relevant models of the most deadly CNS pediatric cancers; how deciphering the mechanism of action of a natural product, taxol, catalyzed breakthroughs in cancer therapy; and discovering small molecules that disrupt protein interactions, which cancers depend upon.


William Evans - St. Jude Children's Research Hospital

Precision Medicine of Childhood Acute Lymphoblastic Leukemia: From Discovery to Translation

Susan Band Horwitz - Albert Einstein College of Medicine

Taxol®, Tubulin and Tumors: A Story of Drug Development

Martine Roussel - St. Jude Children's Research Hospital

Identification of New Therapies to Treat Pediatric Medulloblastoma

R. Kiplin Guy - University of Kentucky School of Pharmacy

Discovery of Inhibitors of the Interaction of UBC12 and DCN1