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Can Metabolic Vulnerabilities in Tumors be Therapeutically Exploited?

Tuesday April 24, 2018

9:30 am - 12:00 pm

Room 15A
Sponsored by the Division for Cancer Pharmacology (DCP)
Co-sponsored by the Division for Molecular Pharmacology (MP)
Co-sponsored by the Division for Translational and Clinical Pharmacology (TCP)

Chair :

Susan Cole
Queen's University at Kingston

Koen van de Wetering
Thomas Jefferson University

Many metabolic pathways are altered in cancer cells, which sometimes rely heavily on specific nutrients. Significant progress has been made in recent years in our understanding of how these metabolic changes may lead to vulnerabilities in different tumor types that may be harnessed for therapeutic benefit. This symposium will provide insights into the strategies used to identify these vulnerabilities and how they may be exploited in anticancer therapy.

Modulating the Oncogenic Phenotype with Metabolites
Gary Siuzdak - The Scripps Research Institute

Metabolic Transitions in Cancer: Lessons from Viral Infection
Heather Christofk - University of California, Los Angeles

The Glutamate/Cystine Antiporter SLC7A11/xCT Regulates Glucose Dependency in Cancer Cells: Mechanism and Therapeutic Implications
Boyi Gan - The University of Texas MD Anderson Cancer Center

ABBC5: A Multidrug Efflux Transporter with an Unusual Substrate Spectrum
Koen van de Wetering - Thomas Jefferson University

Raloxifene Compromises Mitochondria, Induces ROS Stress and the Unfolded Protein Response, and Synergizes Gemcitabine's Cytotoxicity in Pancreatic Cancer Cells
Heather True - School of Pharmacy, Pacific University Oregon

Molecular Targeting and Inactivation of Glutaminase and CDK4/6 in Mantle Cell Lymphoma
Bettine Gibbs - Butler University

Thank you to our Annual Meeting partners:

University of Florida
Wake Forest University
Washington State University College of Pharmacy and Pharmaceutical Sciences
University of Wisconsin Molecular and Cellular Pharmacology Training Program
UT Health San Antonio
University of Minnesota

Emory University Pharmacology

PR & P
University of Michigan Medical School Pharmacology