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Julius Axelrod Symposium: The Pluridimensionality of G Protein-Coupled Receptor (GPCR) Signaling

Tuesday April 24, 2018

9:30 am - 12:00 pm Eastern Time (ET)

Room 16A


Chair :

Michel Bouvier
Université de Montréal

Ali Salahpour
University of Toronto

It has become clear that GPCR can transduce signal using a much greater diversity of modalities than originally anticipated. Far from being linear communication lines, GPCR signaling pathways are more akin to web-like structures involving many different partners and mechanisms underlying the spatiotemporal propagation of diverse signals. In recent years, the concepts of biased-signaling and organelle-specific signaling are changing our vision of how the receptors and their signaling partners can be pharmacologically targeted for the development of better and safer drugs. The symposium will explore the multiple dimensions of GPCR signaling, the mechanisms controlling their selectivity and efficacy with a special focus on the possibility of harnessing this knowledge for the discovery of innovative therapies.


Marc von Zastrow - University of California, San Francisco

Intracellular Propagation of GPCR Signaling

Stephane Laporte - McGill University-MUHC

Study of the Biased Signaling and Trafficking of the Angiotensin II Type 1 Receptor

Stefano Marullo - Université Paris-Descartes-Institut Cochin

A Pathogen Reveals Hidden Aspects of B2-Adrenergic Receptor Functioning

Stephane Angers - University of Toronto

Genome-Wide CRISPR Screens Reveal Wnt-Frizzled Functional Selectivity in Pancreatic Cancer

Marc Caron - Duke University

GRKs and Arrestins-Based Bias in the Neuronal Function of GPCRs