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Julius Axelrod Symposium: The Pluridimensionality of G Protein-Coupled Receptor (GPCR) Signaling

Tuesday April 24, 2018

9:30 am - 12:00 pm

Room 16A
Co-sponsored by the Division for Cardiovascular Pharmacology (CVP)
Co-sponsored by the Division for Drug Discovery and Development (DDD)
Co-sponsored by the Division for Neuropharmacology (NEU)

Chair :

Michel Bouvier
Université de Montréal

Ali Salahpour
University of Toronto

It has become clear that GPCR can transduce signal using a much greater diversity of modalities than originally anticipated. Far from being linear communication lines, GPCR signaling pathways are more akin to web-like structures involving many different partners and mechanisms underlying the spatiotemporal propagation of diverse signals. In recent years, the concepts of biased-signaling and organelle-specific signaling are changing our vision of how the receptors and their signaling partners can be pharmacologically targeted for the development of better and safer drugs. The symposium will explore the multiple dimensions of GPCR signaling, the mechanisms controlling their selectivity and efficacy with a special focus on the possibility of harnessing this knowledge for the discovery of innovative therapies.

Intracellular Propagation of GPCR Signaling
Marc von Zastrow - University of California, San Francisco

Study of the Biased Signaling and Trafficking of the Angiotensin II Type 1 Receptor
Stephane Laporte - McGill University-MUHC

A Pathogen Reveals Hidden Aspects of B2-Adrenergic Receptor Functioning
Stefano Marullo - Université Paris-Descartes-Institut Cochin

Genome-Wide CRISPR Screens Reveal Wnt-Frizzled Functional Selectivity in Pancreatic Cancer
Stephane Angers - University of Toronto

GRKs and Arrestins-Based Bias in the Neuronal Function of GPCRs
Marc Caron - Duke University

Thank you to our Annual Meeting partners:

University of Florida
Wake Forest University
Washington State University College of Pharmacy and Pharmaceutical Sciences
University of Wisconsin Molecular and Cellular Pharmacology Training Program
UT Health San Antonio
University of Minnesota

Emory University Pharmacology

PR & P
University of Michigan Medical School Pharmacology