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ncRNAs in Drug Metabolism and the Translation of Gene Silencing Technology into Therapeutics

Sunday April 07, 2019

8:00 am - 10:00 am

Room W206 C
Sponsored by the Division for Drug Metabolism and Disposition (DMDD)
Co-sponsored by the Division for Cardiovascular Pharmacology (CVP)
Co-sponsored by the Division for Drug Discovery and Development (DDD)
Co-sponsored by Division for Toxicology (TOX)

Chair :

Baitang Ning
Natl Ctr for Toxicological Research, FDA

Julie Lade
Amgen, Inc. USA

Piled evidence has demonstrated that non-coding RNAs (ncRNAs) play an important role in mediating the inter-individual variability observed in drug metabolism through the modulation of genes encoding drug metabolizing enzymes and transporters (DMETs) in addition to nuclear receptors. In contrast to the mechanism by which endogenous ncRNAs impact gene expression, synthetic interfering RNA (siRNA) has become rapidly under investigation as a therapeutic strategy to inhibit the translation of messenger RNA in an effort to treat human diseases. This symposium will provide a blended overview of recent research pertaining to ncRNAs and exogenous oligonucleotides within the context of drug metabolism and gene silencing, respectively.

Functional Characterization of ncRNAs in the Regulation of CYPs
Dianke Yu - School of Public Health, Qingdao University

Regulation of UGTs by MicroRNAs and Drug Toxicity
Michael Court - Washington State University, USA

Inhibition of Drug Metabolizing Enzymes and Drug Transporters by Phosphodiester- or Phosphorothioate-linked Oligonucleotides
Faraz Kazmi - Janssen Research & Development

siRNA-protein Interactions in the Context of siRNA-based Therapeutics
Sara Humphreys - PKDM, Amgen Inc.

Bioengineering of Single ncRNA Molecule for Multi-Targeting Against NSCLC
Hannah Petrek - UC Davis

Thank you to our Annual Meeting partners:

University of Florida
Wake Forest University
Washington State University College of Pharmacy and Pharmaceutical Sciences
University of Wisconsin Molecular and Cellular Pharmacology Training Program
UT Health San Antonio
University of Minnesota

Emory University Pharmacology

PR & P
University of Michigan Medical School Pharmacology