In This Section

Novel Genetic-based Tools for Toxicity Screening, Precision Medicine, and Mode of Action Analysis

Tuesday April 24, 2018

3:30 pm - 6:00 pm Eastern Time (ET)

Room 15A


Chair :

Brian Cummings
University of Georgia

Alison Harrill
National Institute of Environmental Health Sciences / NIH

Novel tools that evaluate the genetic drivers and transcriptional responses to drug and chemical exposures have the potential to add important insights into toxicology evaluation. In this session, novel tools will be described that demonstrate utility for safety and risk assessment pipelines. These tools span (1) DNA methylation analysis, rodent population models that enable assessment of human population dynamics in susceptibility and avenues for precision medicine, (2) high-throughput transcriptomic screens that enable sensitive measures of chemical potency, (3) gene expression network analysis that informs intracellular chemical effects, and (4) yeast genetic screens that identify genetic susceptibility factors and inform toxicity mode of action.


Brian Cummings - University of Georgia

Novel Methods for Rapid Assessment of Toxicant-Induced Changes in DNA Methylation: Alternatives to Pyrosequencing and Methylome Analysis

Joshua Harrill - U.S. Environmental Protection Agency

High-Throughput Transcriptomics in in vitro Chemical Screens, a Sensitive Tool for Benchmark Dose Assessment

Yue Wang Webster - Lilly Research Laboratories

Weighted Gene Co-Expression Network Analysis (WGCNA): Systems Biology Approaches to Understanding Adverse Outcomes

Alison Harrill - National Institute of Environmental Health Sciences / NIH

Diversity Outbred Mice – A Genetic Reference Population That Enabling Risk Predictions for Sensitive Subpopulations

Daniel Gatti - The Jackson Laboratory

Pharmacogenetic Assessment of Drug Toxicity Using Diversity Outbred Mice

Chris Vulpe - University of Florida

Genome Wide and Targeted CRISPR Functional Approaches in Toxicology