In This Section

Novel Genetic-based Tools for Toxicity Screening, Precision Medicine, and Mode of Action Analysis

Tuesday April 24, 2018

3:30 pm - 6:00 pm

Room 15A
Sponsored by the Division for Toxicology (TOX)

Chair :

Brian Cummings
University of Georgia

Alison Harrill
National Institute of Environmental Health Sciences / NIH


Novel tools that evaluate the genetic drivers and transcriptional responses to drug and chemical exposures have the potential to add important insights into toxicology evaluation. In this session, novel tools will be described that demonstrate utility for safety and risk assessment pipelines. These tools span (1) DNA methylation analysis, rodent population models that enable assessment of human population dynamics in susceptibility and avenues for precision medicine, (2) high-throughput transcriptomic screens that enable sensitive measures of chemical potency, (3) gene expression network analysis that informs intracellular chemical effects, and (4) yeast genetic screens that identify genetic susceptibility factors and inform toxicity mode of action.

Novel Methods for Rapid Assessment of Toxicant-Induced Changes in DNA Methylation: Alternatives to Pyrosequencing and Methylome Analysis
Brian Cummings - University of Georgia

High-Throughput Transcriptomics in in vitro Chemical Screens, a Sensitive Tool for Benchmark Dose Assessment
Joshua Harrill - U.S. Environmental Protection Agency

Weighted Gene Co-Expression Network Analysis (WGCNA): Systems Biology Approaches to Understanding Adverse Outcomes
Yue Wang Webster - Lilly Research Laboratories

Diversity Outbred Mice – A Genetic Reference Population That Enabling Risk Predictions for Sensitive Subpopulations
Alison Harrill - National Institute of Environmental Health Sciences / NIH

Pharmacogenetic Assessment of Drug Toxicity Using Diversity Outbred Mice
Daniel Gatti - The Jackson Laboratory

Genome Wide and Targeted CRISPR Functional Approaches in Toxicology
Chris Vulpe - University of Florida

Thank you to our Annual Meeting partners:

Amgen
University of Florida
Wake Forest University
Washington State University College of Pharmacy and Pharmaceutical Sciences
University of Wisconsin Molecular and Cellular Pharmacology Training Program
UT Health San Antonio
University of Minnesota

Emory University Pharmacology

PR & P
University of Michigan Medical School Pharmacology
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