In This Section

Placental Xenobiotic Metabolism and Transport

Sunday April 22, 2018

9:30 am - 12:00 pm Eastern Time (ET)

Room 15A


Chair :

Lauren Aleksunes
Rutgers University

Qingcheng Mao
University of Washington

Fetal exposure to drugs/xenobiotics can be dependent on metabolism and transport by the placenta. To assess developmental toxicities of drugs/xenobiotics, it is critical to understand the mechanisms that control metabolism and trafficking of drugs/xenobiotics across the placental barrier. This workshop highlights the most recent knowledge of the interactions of drugs and xenobiotics with transporters and drug-metabolizing enzymes in human placenta. The purpose of this symposium is to bring together experts in drug transport/metabolism and toxicology to highlight the mechanisms that control drug/xenobiotic disposition in the placenta and impact on fetal drug/xenobiotic exposure and response.


Mahmoud Ahmed - University of Texas - Medical Branch, Galveston

Placental Metabolism of Drugs and Impacts on Fetal Exposure

Lauren Aleksunes - Rutgers University

Placental Transporter Regulation and Environmental Toxicant Interactions

Qingcheng Mao - University of Washington

Fetal Exposure to Drugs: Role of Placental Transporters

Mailys De Sousa Mendes - Simcyp

PBPK Modeling and Simulation to Predict Fetal Exposure to Drugs and Xenobiotics

Naveen Neradugomma - University of Washington

Effects of Cannabinoids on Trophoblast Cell Growth and Syncytialization

Phoebe Stapleton - Rutgers University

Translocation of Engineered Nanomaterials from the Maternal Lungs to the Fetal Compartment After Instillation