In This Section

Placental Xenobiotic Metabolism and Transport

Sunday April 22, 2018

9:30 am - 12:00 pm

Room 15A
Sponsored by the Division for Toxicology (TOX)
Co-sponsored by the Division for Drug Discovery and Development (DDD)
Co-sponsored by the Division for Drug Metabolism and Disposition (DMDD)

Chair :

Lauren Aleksunes
Rutgers University

Qingcheng Mao
University of Washington


Fetal exposure to drugs/xenobiotics can be dependent on metabolism and transport by the placenta. To assess developmental toxicities of drugs/xenobiotics, it is critical to understand the mechanisms that control metabolism and trafficking of drugs/xenobiotics across the placental barrier. This workshop highlights the most recent knowledge of the interactions of drugs and xenobiotics with transporters and drug-metabolizing enzymes in human placenta. The purpose of this symposium is to bring together experts in drug transport/metabolism and toxicology to highlight the mechanisms that control drug/xenobiotic disposition in the placenta and impact on fetal drug/xenobiotic exposure and response.

Placental Metabolism of Drugs and Impacts on Fetal Exposure
Mahmoud Ahmed - University of Texas - Medical Branch, Galveston

Placental Transporter Regulation and Environmental Toxicant Interactions
Lauren Aleksunes - Rutgers University

Fetal Exposure to Drugs: Role of Placental Transporters
Qingcheng Mao - University of Washington

PBPK Modeling and Simulation to Predict Fetal Exposure to Drugs and Xenobiotics
Mailys De Sousa Mendes - Simcyp

Effects of Cannabinoids on Trophoblast Cell Growth and Syncytialization
Naveen Neradugomma - University of Washington

Translocation of Engineered Nanomaterials from the Maternal Lungs to the Fetal Compartment After Instillation
Phoebe Stapleton - Rutgers University

Thank you to our Annual Meeting partners:

Amgen
University of Florida
Wake Forest University
Washington State University College of Pharmacy and Pharmaceutical Sciences
University of Wisconsin Molecular and Cellular Pharmacology Training Program
UT Health San Antonio
University of Minnesota

Emory University Pharmacology

PR & P
University of Michigan Medical School Pharmacology
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