In This Section

Surmounting the Insurmountable: Obstacles in Drug Discovery and Development - Real World Case Studies

Monday April 23, 2018

9:30 am - 12:00 pm

Room 16A
Co-sponsored by the Division for Behavioral Pharmacology (BEH)
Co-sponsored by the Division for Cancer Pharmacology (DCP)
Co-sponsored by the Division for Drug Discovery and Development (DDD)
Co-sponsored by the Division for Drug Metabolism and Disposition (DMDD)
Co-sponsored by the Division for Translational and Clinical Pharmacology (TCP)

Chair :

Kan He
Biotranex

Paul Hollenberg
University of Michigan


During the drug discovery and development process in the real world, expert scientists frequently encounter an unexpected obstacle that seems insurmountable. Serious issues with efficacy, toxicity, and pharmacokinetics may unexpectedly threaten the successful development of the whole project. How do experienced scientists deal with such issues? Critical thinking and problem solving are essential for success. This session features recognized experts in drug discovery and development and their fascinating and challenging stories. What went fatally wrong with a particular drug? How was the problem solved?

Challenges and Solutions in the Approval of Austedo, the First Deuterium-Substituted Small Molecule
Margaret Bradbury - Prana Biotech

Discovery and Development Challenges of Dasatinib for the Treatment of Chronic Myelogenous Leukemia and Beyond
Francis Lee - Angex Pharmaceutical Inc.

Modeling and Simulation that Resulted in the Progression of Evolucumab
Sandeep Dutta - Amgen

Fasiglifam (TAK-875) Alters Bile Acid Homeostasis in Rats and Dogs: A Potential Cause of Drug Induced Liver Injury
Francis Wolenski - Takeda Pharmaceuticals International Co.

Conclusion
Paul Hollenberg - University of Michigan

Thank you to our Annual Meeting partners:

Amgen
University of Florida
Wake Forest University
Washington State University College of Pharmacy and Pharmaceutical Sciences
University of Wisconsin Molecular and Cellular Pharmacology Training Program
UT Health San Antonio
University of Minnesota

Emory University Pharmacology

PR & P
University of Michigan Medical School Pharmacology
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