Despite the decline in tobacco smoking, usage of electronic cigarettes (e-cigarettes) has been rising since their introduction in 2007. This trend, which is mainly due to the provocative claim that they are/were a healthier alternative to tobacco smoking, has continued even during the COVID-19 pandemic. Our studies have documented that e-cigarettes, including in utero exposure, increase the risk of occlusive cardiovascular disease, by triggering a state of platelet hyperreactivity.