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The Bright and Dark Side of Nrf2 for Tissue Protection

Monday April 23, 2018

9:30 am - 12:00 pm

Room 15B
Sponsored by the Division for Toxicology (TOX)

Chair :

Qin Chen
University of Arizona


Nrf2 gene encodes a transcription factor known for regulating antioxidant and detoxification genes. Genome wide studies have revealed Nrf2 control over 600 genes, including genes for anabolic metabolism, cell proliferation and extracellular matrix remodeling. Keap1 mediated Nrf2 ubiquitination can be hijacked by small molecules from natural products for inducing Nrf2 and tissue protection. Keap1 independent mechanisms have been recently reported for Nrf2 activation and tissue protection. Mutation or hyperactivation consists the dark side of Nrf2 due to its participation in cancer cell proliferation and resistance to treatment. The symposium presents the latest findings from the experts in Nrf2 research.

Canonical and Non-canonical Pathways of Nrf2 Activation
Donna Zhang - University of Arizona

Nrf2 as a Therapeutic Target for Treatment of Neurodegenerative Diseases
Jeffrey Johnson - University of Wisconsin

Keap 1 Independent Mechanism of Nrf2 Protection Against Liver Injury
Thomas Kensler - University of Pittsburgh

The Interplay of MicroRNAs and Nrf2 Inducers in Diabetic Complications
Lu Cai - University of Louisville

NFE2L2 (Nrf2) Attenuates Tgf-β1 Signaling by Elevation of Smad7 in Mouse Mesangial MES-13 Cells
Min-Kyun Song - The Catholic University of Korea

Thank you to our Annual Meeting partners:

Amgen
University of Florida
Wake Forest University
Washington State University College of Pharmacy and Pharmaceutical Sciences
University of Wisconsin Molecular and Cellular Pharmacology Training Program
UT Health San Antonio
University of Minnesota

Emory University Pharmacology

PR & P
University of Michigan Medical School Pharmacology
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