In This Section

The Organization of Signal Transduction and Its Impact on Receptor Function

Wednesday April 25, 2018

8:30 am - 11:00 am Eastern Time (ET)

Room 16A


Chair :

John Streicher
University of Arizona

The objectives for this symposium are: 1) Explore crucial mechanisms of signal transduction organization, including chaperone/sequestering proteins, scaffold proteins, endocytosis, and selective signaling regulator interaction; 2) Emphasize the importance of these understudied mechanisms in fields of interest, including opioid signaling, serotonin neurophysiology, and cancer survival signaling; 3) Illustrate the need for future study into the mechanisms of signal transduction regulation, and how these mechanisms influence physiological outcomes; 4) Suggest novel means by which signal transduction can be manipulated to improve therapeutic outcomes; and 5) Illustrate common themes and mechanisms of signaling regulation between the receptors and physiological processes explored.


Jeffrey Benovic - Thomas Jefferson University

Dissecting the Dynamics of GPCR Interaction with GRKs and Arrestins

Adriano Marchese - Medical College of Wisconsin

Compartmentalized Survival Signaling via the Chemokine Receptor CXCR4

Ana Carneiro - Vanderbilt University

The Role of Integrin Proteins in Coordinating Serotonin Synaptic Signaling and Neurotransmitter Reuptake

Nathaniel Jeske - University of Texas Health Science Center at San Antonio

Dynamic Opioid Receptor Regulation in the Periphery

John Streicher - University of Arizona

Heat Shock Protein 90 Promotes Opioid Anti-Nociception in the Brain and Reduces Opioid Anti-Nociception in the Spinal Cord Through Differential Regulation of ERK MAPK

Gary Mo - University of California, San Diego

Live-cell Super-resolution Imaging of PKA Activity Reveals Microdomain Organization and Regulation