In This Section

The Organization of Signal Transduction and Its Impact on Receptor Function

Wednesday April 25, 2018

8:30 am - 11:00 am

Room 16A
Sponsored by the Division for Molecular Pharmacology (MP)
Co-sponsored by the Division for Cardiovascular Pharmacology (CVP)
Co-sponsored by the Division for Drug Discovery and Development (DDD)
Co-sponsored by the Division for Pharmacology Education (DPE)

Chair :

John Streicher
University of Arizona

The objectives for this symposium are: 1) Explore crucial mechanisms of signal transduction organization, including chaperone/sequestering proteins, scaffold proteins, endocytosis, and selective signaling regulator interaction; 2) Emphasize the importance of these understudied mechanisms in fields of interest, including opioid signaling, serotonin neurophysiology, and cancer survival signaling; 3) Illustrate the need for future study into the mechanisms of signal transduction regulation, and how these mechanisms influence physiological outcomes; 4) Suggest novel means by which signal transduction can be manipulated to improve therapeutic outcomes; and 5) Illustrate common themes and mechanisms of signaling regulation between the receptors and physiological processes explored.

Dissecting the Dynamics of GPCR Interaction with GRKs and Arrestins
Jeffrey Benovic - Thomas Jefferson University

Compartmentalized Survival Signaling via the Chemokine Receptor CXCR4
Adriano Marchese - Medical College of Wisconsin

The Role of Integrin Proteins in Coordinating Serotonin Synaptic Signaling and Neurotransmitter Reuptake
Ana Carneiro - Vanderbilt University

Dynamic Opioid Receptor Regulation in the Periphery
Nathaniel Jeske - University of Texas Health Science Center at San Antonio

Heat Shock Protein 90 Promotes Opioid Anti-Nociception in the Brain and Reduces Opioid Anti-Nociception in the Spinal Cord Through Differential Regulation of ERK MAPK
John Streicher - University of Arizona

Live-cell Super-resolution Imaging of PKA Activity Reveals Microdomain Organization and Regulation
Gary Mo - University of California, San Diego

Thank you to our Annual Meeting partners:

University of Florida
Wake Forest University
Washington State University College of Pharmacy and Pharmaceutical Sciences
University of Wisconsin Molecular and Cellular Pharmacology Training Program
UT Health San Antonio
University of Minnesota

Emory University Pharmacology

PR & P
University of Michigan Medical School Pharmacology