In This Section

Tissue Free Drug Concentrations

Wednesday April 25, 2018

8:30 am - 11:00 am

Room 15B
Sponsored by the Division for Drug Metabolism and Disposition (DMDD)
Co-sponsored by the Division for Cancer Pharmacology (DCP)

Chair :

Donglu Zhang

Julie Lade

Under thermodynamic conditions, the free drug concentration in tissues should equal to that in circulation. However, drug disposition factors such as antigen‐/drug transporters‐mediated uptake, and other common properties such as tissue accumulation and covalent binding kinetically alter drug forms and concentrations in tissues. In turn, the actual drug free concentrations in tissues instead of that in circulation determine efficacy and toxicity of a drug. This session will focus on examples to support the importance of tissue concentration of a drug or metabolites that is a critical parameter but often missing in drug discovery and development.

Exceptions to Free Drug Assumption
Donglu Zhang - Genentech

Pursuing the Holy Grail of Predicting and Verifying Tissue Drug Concentrations: A Proteomics and PET-imaging Approach
Jashvant Unadkat - University of Washington

Target Tissue Drug Concentrations are Critical for the Efficacy of Antibiotics and Anti-viral Drugs
Lijuan Jiang - Enanta Pharmaceuticals

Pharmacokinetics, Metabolism, and Biodistribution of a Liver-targeted siRNA Therapeutic
Julie Lade - Amgen

High-Resolution Imaging MALDI Mass Spectrometry to Assess Label-Free Drug Disposition in Tissues
Sheerin Shahidi-Latham - Genentech

MALDI Mass Spectrometry Imaging Reveals Heterogenous Distribution of Tenofovir and Tenofovir-Diphosphate in Human Colorectal Tissue
Herana Seneviratne - Johns Hopkins University School of Medicine

Delivery of Active Drug Concentrations to Brain Tumor Targets
Gautham Gampa - University of Minnesota

Thank you to our Annual Meeting partners:

University of Florida
Wake Forest University
Washington State University College of Pharmacy and Pharmaceutical Sciences
University of Wisconsin Molecular and Cellular Pharmacology Training Program
UT Health San Antonio
University of Minnesota

Emory University Pharmacology

PR & P
University of Michigan Medical School Pharmacology