In This Section

Transporters at the Blood-CNS Barriers

Monday April 23, 2018

9:30 am - 12:00 pm

Room 17A
Sponsored by the Division for Drug Metabolism and Disposition (DMDD)
Co-sponsored by the Division for Behavioral Pharmacology (BEH)
Co-sponsored by the Division for Cancer Pharmacology (DCP)
Co-sponsored by the Division for Neuropharmacology (NEU)
Co-sponsored by the Division for Pharmacology Education (DPE)
Co-sponsored by Division for Toxicology (TOX)

Chair :

Patrick Ronaldson
University of Arizona

Joanne Wang
University of Washington


The delivery of drugs into the central nervous system (CNS) is greatly hindered by the blood-brain barrier (BBB) and the blood-CSF barrier (BCSFB). Emerging evidence suggests that uptake and efflux transporters expressed at these CNS barriers are an important determinant of brain exposure and CNS activity or toxicity of many drugs and neuroactive agents. This symposium will highlight recent advancement in our understanding of the mechanisms, regulation and in vivo significance of ABC and SLC transporters at the BBB and BCSFB.

Quantifying Drug Transport at the Blood-Brain Barrier and the Role of Uptake and Efflux Transporters
Margareta Hammarlund-Udenaes - Uppsala University

Targeting Blood-Brain Barrier Transporters for CNS Drug Delivery: Role of Transforming Growth Factor-Beta Signaling
Patrick Ronaldson - University of Arizona

Influence of Peptide Transporter 2 (PEPT2) on the Brain Disposition/Dynamics of Peptides and Peptide-Like Drugs
David Smith - University of Michigan

Molecular Pathways of Organic Cation and Anion Transport at the Blood‐CSF Barrier
Joanne Wang - University of Washington

Is Inhibitor Binding the Sole Requirement in Determining Inhibition of ABCG2 Mediated Transport?
Tomoka Gose - St. Jude Children's Research Hospital

Thank you to our Annual Meeting partners:

Amgen
University of Florida
Wake Forest University
Washington State University College of Pharmacy and Pharmaceutical Sciences
University of Wisconsin Molecular and Cellular Pharmacology Training Program
UT Health San Antonio
University of Minnesota

Emory University Pharmacology

PR & P
University of Michigan Medical School Pharmacology
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