In This Section

Virtual Pharmacology and Experimental Therapeutics: Near or Distant?

Sunday April 07, 2019

3:00 pm - 5:00 pm Eastern Time (ET)

Room W206 C


Chair :

C. Anthony Hunt
University of California, San Francisco

Given a plausible mechanism-based explanation of a pharmacological phenomenon, it is now feasible to build a virtual version of that explanation in software. The model mechanism and its generated phenomenon can be incrementally improved to become strongly analogous to actual counterparts. By so doing, we open a door to designing and conducting scientifically useful virtual experiments. The symposium will provide three examples of early stage virtual pharmacology, physiology, and therapeutics; show how the approach and methods can become scientifically and clinically productive; and describe how methods and tools are being adapted from engineering domains to improve transparency and credibility.


Denise Kirschner - University of Michigan Medical School

A Multi-scale Systems Pharmacology Approach to Virtual Therapeutics: Optimizing Drugs, Regimens and Dosing

Gary An - University of Vermont

Systems Pharmacology as a Complex Control Problem: The Role of Simulation-aided Design

C. Anthony Hunt - University of California, San Francisco

Exploring Plausible Virtual Model Mechanisms that Better Explain Acetaminophen Hepatotoxicity

Jon Timmis - University of York

Engineering Scientifically Productive Biological Simulations: Tools and Methods from Systems Safety Engineering to Facilitate Translation