In This Section

Novel and Integrated Intestine-liver Crosstalk on Hepatic Xenobiotic Metabolism

Sunday April 05, 2020

8:00 am - 10:00 am Eastern Time (ET)

Room 15 A


Chair :

Hongbing Wang
University of Maryland

Grace Guo
Rutgers Univ - Ernest Mario Sch of Pharmacology

The liver stays in the center of drug metabolism that is regulated by xenobiotic receptors and endocrine factors during development, physiology and pathology. The intestine and liver are closely interacted and a role of intestine derived factors is emerging in critically regulating the endobiotic and xenobiotic metabolism in the liver. Novel medicine or technologies to treat human diseases will be developed inspired by these interactions. This symposium will bring the best knowledge, novel in vitro and in vivo technology, and application of intestine-liver crosstalk to audience with interest in novel drug development and pharmacology.


Andrew Patterson - Penn State University

The Aryl Hydrocarbon Receptor as a Moderator of Host-microbiota Communication

Masahiko Negishi - National Institute of Environmental Health Sciences (NIEHS), NIH

Activation of Xenobiotic Receptor by Endocrine Signaling Pathways

Shiew-Mei Huang - US Food and Drug Administration

Emerging Role of Organ-on-a-Chip Technologies in Quantitative Clinical Pharmacology Evaluation

Murat Cirit - Javelin Biotech

Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies

Guo Zhong - University of Washington

Postnatal Loss of Cyp26a1 and Cyp26b1 in Mice causes Impaired retinoid Homeostasis in Multiple Organs

Last Updated: December 10, 2020
Key Dates
March 6

Housing discounts end

March 13

Advance Registration Ends

April 3-4

GPCR Colloquium (separate ticket required)

April 4

ASPET Business Meeting and Awards Presentation

April 4-7

ASPET Annual Meeting at EB 2020

Thank you to our Annual Meeting partners:

University of Kentucky
Icahn School
University of Georgia
University of Minnesota
WSU Pharm-Pharm Sciences Unit
PR & P