Division for Molecular Pharmacology Early Career Awards and Postdoc Competition
Friday April 30, 2021
Central Time (CT)
View session on the EB Virtual Platform (EB registration required)
The Scripps Research Institute
Univ of California, San Diego
This award competition features oral presentations from postdoctoral trainees selected from the submitted abstracts as well as keynote lectures from winners of the ASPET Division for Molecular Pharmacology Early Career Award.
- Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases
Gq Signaling in Adipocytes is a Key Regulator of Systemic Glucose and Lipid Homeostasis
- Stony Brook University
RNF8 Stabilizes MYC via K63-linked Ubiquitination to Promote Metabolic Reprogramming in Triple-negative Breast Cancer
- National Cancer Institute
TNIK, A Novel Activator of FAK and YAP Signaling, is a Therapeutic Target in Lung Squamous Cell Carcinoma
- Purdue University
Structure of the Rhodopsin–rhodopsin Kinase Complex Defines the Rules of Engagement between G protein-coupled Receptors (GPCRs) and GPCR Kinases
- Monash University
Molecular Neuropharmacology of Metabotropic Glutamate Receptor 5 Allosteric Modulators
Using rigorous analytical methods we dissect the molecular basis and functional consequences of metabotropic glutamate receptor 5 allosteric modulation. We link these insights to efficacy in preclinical models for psychiatric and neurodegenerative diseases. We aim to improve future rational discovery campaigns for allosteric modulators that optimally fine-tune receptor activity.
- Purdue University
A Structure-Based Approach to Understanding Phospholipase C Function
Phospholipase C (PLC) beta and epsilon increase intracellular Ca2+ and PKC activity in response to their direct interactions with G proteins, which target them to membranes and exert allosteric control. Here I describe efforts to tease apart the mechanisms by which G proteins and membranes themselves regulate PLC.