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Minutes: Executive Committee Meeting/Business Meeting, ASPET Division for Toxicology, April 11, 2011

June 26, 2012

ASPET Division for Toxicology Executive Committee and Business Meeting Minutes

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Walter E. Convention Center room 143C, Washington, DC
April 11, 2011

In attendance – John Schuetz (Chair), Wayne Backes, Lauren Brignac-Huber, Patricia Ganey, Jack Hinson, Qiang Ma, Todd Porter, Courtney Sulentic, and Mary Vore (ASPET Council Liaison)

Dr. John Schuetz called the meeting to order.  After introductions, Dr. Schuetz announced the election results and welcomed Dr. Hinson as Chair-elect and Dr. Monica Valentovic (not present at the business meeting) as Secretary/Treasurer-elect; positions are effective July 2011.   Dr. Schuetz also noted that some ASPET divisions have as many as 17 members on the Executive Committee by inviting non-elected nominees to join the executive committee.  The current committee discussed this as an option with the potential benefit of having a larger pool of members to draw on for suggestions for symposia topics and other matters relevant to the division.  The potential drawbacks were thought to be largely logistical (i.e. efficient communication, meeting attendance quorum and decision making).  The committee did not make a final decision regarding this option.  

Division Reports

Division Symposia

EB2011

The division organized and sponsored one division symposium: Hypoxia, Hypoxia-Inducible Factor-1a and Toxic Responses (P.E. Ganey) and sponsored four other symposia: (1) Drug Metabolism and Action in Pathophysiological Conditions (R. Ghose and E.T. Morgan); (2) Idiosyncratic Drug Reactions (C. Ju); (3) Organ-Specific Toxicities Caused by Novel Metabolic Pathways (K. Skordos and D. Zhang); (4) Pharmacogenomics to Address Adverse Drug Events (D.L. Mendrick and P.B. Watkins).  The division also co-sponsored four symposia: (5) Therapeutic Peptides: Novel Approaches in Drug Development (S. Alagarsamy and M.A. Holinstat); (6) microRNA Controlled Regulation of Drug Metabolism and Disposition (T. Yokoi and A. Yu); (7) Systems Biology of Oxidative Stress and Therapeutic Implications (I. Laher); (8) Pharmacogenomics and Personalized Medicine (A. Gaedigk and J. Paul).

EB2012

There are three proposed symposia: (1) Pharmacogenetics in Oncology (H. Swanson); (2) From Structure to Knockout: Common themes between Cyps and transporters (M. Vore); (3) Nuclear Receptors and human disease (H. Swanson and J. Chiang).

Due to concerns from ASPET regarding Divisions carrying over a large unspent surplus each year, Dr. Schuetz initiated a discussion of using Division funds to support an all-day symposia for 2013 potentially co-sponsored with the Drug Metabolism Division.  Interest was generated but there was concern that an adequate amount of emphasis and visibility be duly placed on the Toxicology Division.  Dr. Schuetz suggested a potential topic centered on the role of TLR in mediating toxicity with ties to preclinical/clinical applications (Clinical Pharmacology Division could be a co-sponsor) and drug metabolism.  An important outcome (other than drawing down the unspent budget surplus) of an all-day or half-day symposia sponsored by the Toxicology Division would be to attract non-toxicologist and emphasize the cutting-edge research and applications of toxicology as a discipline.

There was also discussion regarding ways to increase student and post-doc involvement in proposing symposia.  Suggestions were: 1) add a post-doctoral representative to the executive council (winner of post-doc poster competition); 2) increase involvement of student and post-doc representative in council activities through e-mail and teleconferences; 3) increase ability of students and post-docs to interact by establishing a link to a student/post-doc e-mail directory and initiating a blog on the Toxicology Division website.

Treasurer’s Report

Dr. Sulentic distributed the division statement of revenue and expense supplied by ASPET which summarized years 2006 through 2011.  The division is in sound financial status and carried over $12,013 in 2011 which is expected to continue.  Due to concerns from ASPET regarding Divisions carrying over a large unspent surplus each year, discussion focused on how best to spend down some of the surplus.  Potential options were 1) sponsor an all-day or half-day symposia co-sponsored with other division(s) (see above); 2) sponsor a Young Investigator Award ($1000-2000 per award); and 3) sponsor a student/post-doc luncheon to increase networking and interaction between students/post-docs in the Toxicology Division.

Funding options for establishing a Young Investigator Award per Christie Carrico are to fund straight from surplus budget or establish an endowment which would require an initial $15,000 for a yearly $650 award or $20,000 for a yearly $1000 award.   It was also suggested at the business meeting to offer the award on alternate years.  With a surplus of $12,013 which appears to increase conservatively by approximately $1000 every year depending on our speaker and mixer expenses, we do not currently have the funds to establish an endowment.  Furthermore, if we decide to establish an endowment, we could not fund some of the other activities suggested above.  This topic requires further discussion and resolution.  

NOTE: The 2010 Business Meeting also discussed the possibility of establishing a Young or Early Career Scientist Award.  That discussion is summarized below:

 “The committee discussed potential opportunities for young scientists. There was mention of having a Toxicology Division platform session. This would allow the division to select students and junior faculty to speak at upcoming EB meetings, providing them valuable speaking experience, and to help promote the careers and visibility of these individuals. There were also suggestions about providing travel awards to young scientists, which would be provided by the division. These would augment the travel awards already in place for students through ASPET. It was mentioned that if the scientific talk is 20 minutes or longer, ASPET will cover the travel costs for the scientist up to $1,000 for domestic speakers. Speakers selected from abstracts for 10-15 minute talks will receive complimentary meeting registration.”

Division Website

Jessica Hammett will replace Diane Perpich as Webmaster.  Several revisions to the website were suggested and discussed including establishing a link to a student/post-doc e-mail directory and creating a blog as mentioned above along with general updating of the website. 

Graduate Student and Post-doctoral Representatives to Division Executive Committee

Lauren Brignac-Huber, our current graduate student representative was present at the Business meeting and contributed significant input to our discussions regarding increasing student and post-doc interaction with the Toxicology Division as discussed above.  The committee also agreed to add a post-doctoral representative to the Executive Council.  It was agreed that the winner of the postdoctoral poster competition would take on the role as representative.  Additionally, like the graduate student representative, the post-doctoral representative would receive a travel award to the EB meeting for the following year provided that an abstract is submitted for the meeting.  There was concern that the representatives may no longer be in a student or post-doctoral position around the time of the EB meeting.  However, there was discussion that such a travel award would provide the opportunity for students/post-docs transitioning to new positions to still attend the EB meeting and continue to take advantage of networking and other opportunities offered at the meeting.

Graduate Student and Postdoctoral Poster Competition Award Winners

The winners of the Toxicology Division Poster Competition for EB 2010 and the awards are:

Postdoctoral Awards:

 1st place & Council Representative: Kosuke Saito - $500 and $600 travel award for EB2012

Title: The K+ Channel KCNK1: CAR-mediated Gene Regulation of Male-specific Induction by PB and Hepatic Hypertrophy

Honorable mention: Rakhee Agarwal - $200

Title: Acetaminophen (APAP)-induced Hepatotoxicity and Protein Nitration in Neuronal Nitric Oxide Synthase (nNOS) Knockout Mice

Graduate Student Awards:

1st place and Council Representative: Jessica Morgan - $500

Title: The ABC Transporter Mrp4 (Abcc4) Plays a Crucial Role in Normal Testosterone Production

2nd place: Elina Pathak – $300

Title: Protective Role of a Manganese Porphyrin in an in vitro Model of Sepsis-induced Renal Injury

3rd place: Christopher Kuhlman - $200

Title: Phenol/Hydroquinone Reduces Lymphocyte Counts and Produces Quinol-Thioether- and 4-Hydroxy-2-nonenal-Modified Proteins: Implications for Benzene-Mediated Hematotoxicity

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