ASPET journal Drug Metabolism and Disposition (DMD) commemorates its 50th Anniversary with a special section titled "Perspective on Drug Metabolism and Disposition." In Part I of the special section DMD associate editors share their insights on specific topics within their areas of expertise, shedding light on significant subjects in the field. Noteworthy articles include:
- In "Human Absorption, Distribution, Metabolism, and Excretion Studies: Origins, Innovations, and Importance,” Dr. R. Scott Obach and colleagues at Pfizer, Inc. offer a historical review exploring the origins of ADME studies, showcasing the advancements made since George de Hevesy's pioneering work, and emphasizing DMD's role as a vital platform for disseminating findings.
- Dr. David S. Riddick's review article, "Fifty Years of Aryl Hydrocarbon Receptor Research as Reflected in the Pages of Drug Metabolism and Disposition," examines the effects of pollutant chemicals on hormone functions and the disruption of hepatic P450 enzymes. It offers a decade-by-decade summary of historical discoveries in the aryl hydrocarbon receptor field.
- "Epigenetic Mechanisms Contribute to Intraindividual Variations of Drug Metabolism Mediated by Cytochrome P450 Enzymes" by Dr. Xiao-bo Zhong and a colleague from the University of Connecticut explores the role of epigenetic modifications, such as DNA methylation and histone modifications, in intraindividual variations of drug metabolism.
- Dr. Aiming Yu and his colleague's contribution, "Recombinant Technologies Facilitate Drug Metabolism, Pharmacokinetics, and General Biomedical Research," highlights the use of bioengineered RNA agents for investigating ADME gene regulation and other areas of biomedical research.
- Dr. Nina Isoherranen and colleagues' review, "Impact of Intracellular Lipid Binding Proteins (iLBPs) on Endogenous and Xenobiotic Ligand Metabolism and Disposition," provides an in-depth examination of various aspects of iLBPs, focusing on their potential contributions to xenobiotic distribution and metabolism.
More articles are forthcoming in Part II of the special section, providing additional perspectives on drug metabolism and disposition. All content in “Perspective on Drug Metabolism and Disposition,” published in DMD’s June 2023 issue (51/6), is freely accessible through December 31, 2023.