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Axelrod Symposium: Phosphoproteomic Analysis of G Protein-Coupled Pathways

Sunday April 07, 2019

3:00 pm - 5:00 pm

Room W205 BC
Co-sponsored by the Division for Behavioral Pharmacology (BEH)
Co-sponsored by the Division for Cardiovascular Pharmacology (CVP)
Co-sponsored by the Division for Molecular Pharmacology (MP)

Chair :

Joe Beavo
University of Washington

Mark von Zastrow
University of California, San Francisco


This symposium will address some of the newer methods of unbiased, phosphoproteomic approaches to the analysis of physiological and pharmacological regulation of G-protein coupled receptor pathways. Several different G-protein coupled pathways will be discussed and compared. Data will be presented about how specific compartmentalization of pathways can be dissected using changes in phosphoproteomic profiles in the presence and absence of pathway selective drugs. There will also be a discussion of how phosphoproteomic analyses can be used in conjunction with cellular imaging techniques to analyze compartmentalized signaling.

Supported by the John V. Croker Fund

Phosphoproteomic Identification of Vasopressin V2 Receptor-Dependent Signaling
Mark Knepper - National Heart, Lung, and Blood Institute

High-resolution Mapping and Systems Analysis of the Prostanoid E Receptor 1-4 (EP1-4) Signaling Network in T Cell Subsets by Quantitative Phosphoproteomics and Phosphoflow Cytometry
Kjetil Taskén - Oslo University Hospital

Defining a Cellular map of cAMP Nanodomains Using Real-time Imaging and Mass Spectrometry
Manuela Zaccolo - University of Oxford

Proteomic Approaches GPCR Signaling and Regulation
Mark von Zastrow - University of California, San Francisco

Last Updated: August 15, 2019
Key Dates
April 6

ASPET Business Meeting and Awards Presentation

April 6-9

ASPET Annual Meeting at EB 2019