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Bridging the Translational Gap in Ischemic Stroke Research

Tuesday April 09, 2019

2:00 pm - 3:30 pm

Room W206 B
Sponsored by the Division for Neuropharmacology (NEU)
Co-sponsored by the Division for Cardiovascular Pharmacology (CVP)
Co-sponsored by the Division for Drug Discovery and Development (DDD)
Co-sponsored by the Division for Translational and Clinical Pharmacology (TCP)

Chair :

Keith Pennypacker
University of Kentucky

Although ischemic stroke is one of the leading causes of death, researchers have failed to translate the success of preclinical studies into novel drugs for treating stroke patients. Some of the main reasons behind this failure to produce clinically relevant therapies include poor animal models, the failure to address the post-stroke immune response, insufficient transportation of drugs across the blood-brain barrier, and the failure to address white matter damage after stroke. Expert researchers will address each of these "problem areas" and provide solutions for future preclinical studies.

Failure to Launch: Why Stroke Treatments Haven't Translated from Rodents to Humans
Keith Pennypacker - University of Kentucky

Treatment with Leukemia Inhibitory Factor Alters Mitochondrial Function and Pro-Inflammatory Cytokine Expression in the Spleens of Aged Rats
Stephanie Davis - University of Kentucky

Regulating Mitochondrial Dynamics to Precondition and Promote Post-Ischemic Axon Function Recovery
Selva Baltan - Cleveland Clinic Lerner Research Institution

Targeting the Blood-Brain Barrier for Delivery of Neuroprotective Drugs in Ischemic Stroke
Patrick Ronaldson - University of Arizona

Modulating the Adaptive Immune Response after Ischemic Stroke
Halina Offner - Oregon Health & Science University

Last Updated: August 15, 2019
Key Dates
April 6

ASPET Business Meeting and Awards Presentation

April 6-9

ASPET Annual Meeting at EB 2019

Thank you to our Annual Meeting partners:

University of Florida
Wake Forest University
Washington State University College of Pharmacy and Pharmaceutical Sciences
University of Wisconsin Molecular and Cellular Pharmacology Training Program
UT Health San Antonio
University of Minnesota

Emory University Pharmacology

PR & P
University of Michigan Medical School Pharmacology