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Drugging DNA Damage Response & Repair: A Layered Therapeutic Approach for Cancer Treatment

Monday April 08, 2019

8:00 am - 10:00 am

Room W205 A
Sponsored by the Division for Cancer Pharmacology (DCP)
Co-sponsored by the Division for Drug Discovery and Development (DDD)
Co-sponsored by the Division for Molecular Pharmacology (MP)
Co-sponsored by the Division for Translational and Clinical Pharmacology (TCP)

Chair :

Robert van Waardenburg
University of Alabama at Birmingham

DNA damage response and repair pathways are at the forefront of molecularly-targeted therapeutic strategies, as tumor-induced defects in DNA repair or checkpoint signaling can be exploited by selective targeting of other repair pathways. This is exemplified by successful targeting of PARP1/2, Chk1/Wee1, and ATM/ATR, as well as additional drug development efforts focused on DNA repair. This symposium highlights resurgent interests in selective targeting of these survival pathways, and how these efforts may be exploited to augment current cancer therapy, topics which are timely and of significant impact in the fields of cancer pharmacology, drug discovery and drug development.

WEE1-Inhibitor Adavosertib (AZD1775) in Clinical Trials
Robert Godin - AstraZeneca

DNA2 Nuclease-helicase Inhibitor, Targeting the Achilles Heel of Cancer Cells
Judith Campbell - California Institute of Technology

The RAD52-ssDNA Interaction Inhibition: Targeting DNA Replication and Repair Interface in BRCA-deficient Cancers
Maria Speis - University of Iowa Carver College of Medicine

Turning the DNA Repair Protein TDP1 into a Cellular Poison as a Potential Strategy for Cancer Treatment
Robert van Waardenburg - University of Alabama at Birmingham

Last Updated: August 15, 2019
Key Dates
April 6

ASPET Business Meeting and Awards Presentation

April 6-9

ASPET Annual Meeting at EB 2019

Thank you to our Annual Meeting partners:

University of Florida
Wake Forest University
Washington State University College of Pharmacy and Pharmaceutical Sciences
University of Wisconsin Molecular and Cellular Pharmacology Training Program
UT Health San Antonio
University of Minnesota

Emory University Pharmacology

PR & P
University of Michigan Medical School Pharmacology