In This Section

Enteric Drug Metabolism and Drug-Drug Interactions

Monday April 08, 2019

2:00 pm - 3:30 pm Eastern Time (ET)

Room W206 B

DDD DMDD TOX

Chair :

Albert Li
In Vitro ADMET Laboratories Inc.



There is a great need to develop experimental approaches to define the roles of enteric drug metabolism, uptake and efflux in the fate and biological effects of the orally-administered drugs. This proposed symposium will a review of the current scientific concepts and experimental approaches in the assessment of intestinal drug uptake, metabolism, drug-drug interactions and enterotoxicity. The presentations will include a review of the current understanding of enteric drug metabolizing enzymes and transporters, in vitro and in vivo experimental approaches, as well as PBPK and IVIVE approaches for the translation of preclinical data to clinical outcome.

Speakers

Kenneth Thummel - University of Washington

A Review of Intestinal Drug Metabolizing Enzymes and Transporters

Albert Li - In Vitro ADMET Laboratories Inc.

In Vitro Experimental Models for the Evaluation of Intestinal Drug Metabolism, Drug-Drug Interactions, and Drug Toxicity

Yuichi Sugiyama - Riken Institute

Kinetic Analyses of Interplay of Uptake (OATP2B1), Efflux (P-gp, BCRP) and Metabolizing Enzyme (CYP3A4) in the Intestinal Absorption of Drugs

Mary Paine - Washington State University

Translational Approaches to Address Potential Clinically Significant Enteric Xenobiotic-Drug Interactions

Last Updated: August 15, 2019
Key Dates
April 6

ASPET Business Meeting and Awards Presentation

April 6-9

ASPET Annual Meeting at EB 2019

Thank you to our Annual Meeting partners:

Amgen
University of Florida
Wake Forest University
Washington State University College of Pharmacy and Pharmaceutical Sciences
University of Wisconsin Molecular and Cellular Pharmacology Training Program
UT Health San Antonio
University of Minnesota

Emory University Pharmacology

PR & P
University of Michigan Medical School Pharmacology
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