Enteric Drug Metabolism and Drug-Drug Interactions
Monday April 08, 2019
Room W206 B
Sponsored by the Division for Toxicology (TOX)
Co-sponsored by the Division for Drug Discovery and Development (DDD)
Co-sponsored by the Division for Drug Metabolism and Disposition (DMDD)
In Vitro ADMET Laboratories Inc.
There is a great need to develop experimental approaches to define the roles of enteric drug metabolism, uptake and efflux in the fate and biological effects of the orally-administered drugs. This proposed symposium will a review of the current scientific concepts and experimental approaches in the assessment of intestinal drug uptake, metabolism, drug-drug interactions and enterotoxicity. The presentations will include a review of the current understanding of enteric drug metabolizing enzymes and transporters, in vitro and in vivo experimental approaches, as well as PBPK and IVIVE approaches for the translation of preclinical data to clinical outcome.
A Review of Intestinal Drug Metabolizing Enzymes and Transporters
- University of Washington
In Vitro Experimental Models for the Evaluation of Intestinal Drug Metabolism, Drug-Drug Interactions, and Drug Toxicity
- In Vitro ADMET Laboratories Inc.
Kinetic Analyses of Interplay of Uptake (OATP2B1), Efflux (P-gp, BCRP) and Metabolizing Enzyme (CYP3A4) in the Intestinal Absorption of Drugs
- Riken Institute
Translational Approaches to Address Potential Clinically Significant Enteric Xenobiotic-Drug Interactions
- Washington State University