In This Section

Enteric Drug Metabolism and Drug-Drug Interactions

Monday April 08, 2019

2:00 pm - 3:30 pm

Room W206 B
Sponsored by the Division for Toxicology (TOX)
Co-sponsored by the Division for Drug Discovery and Development (DDD)
Co-sponsored by the Division for Drug Metabolism and Disposition (DMDD)

Chair :

Albert Li
In Vitro ADMET Laboratories Inc.

There is a great need to develop experimental approaches to define the roles of enteric drug metabolism, uptake and efflux in the fate and biological effects of the orally-administered drugs. This proposed symposium will a review of the current scientific concepts and experimental approaches in the assessment of intestinal drug uptake, metabolism, drug-drug interactions and enterotoxicity. The presentations will include a review of the current understanding of enteric drug metabolizing enzymes and transporters, in vitro and in vivo experimental approaches, as well as PBPK and IVIVE approaches for the translation of preclinical data to clinical outcome.

A Review of Intestinal Drug Metabolizing Enzymes and Transporters
Kenneth Thummel - University of Washington

In Vitro Experimental Models for the Evaluation of Intestinal Drug Metabolism, Drug-Drug Interactions, and Drug Toxicity
Albert Li - In Vitro ADMET Laboratories Inc.

Kinetic Analyses of Interplay of Uptake (OATP2B1), Efflux (P-gp, BCRP) and Metabolizing Enzyme (CYP3A4) in the Intestinal Absorption of Drugs
Yuichi Sugiyama - Riken Institute

Translational Approaches to Address Potential Clinically Significant Enteric Xenobiotic-Drug Interactions
Mary Paine - Washington State University

Last Updated: August 15, 2019
Key Dates
April 6

ASPET Business Meeting and Awards Presentation

April 6-9

ASPET Annual Meeting at EB 2019

Thank you to our Annual Meeting partners:

University of Florida
Wake Forest University
Washington State University College of Pharmacy and Pharmaceutical Sciences
University of Wisconsin Molecular and Cellular Pharmacology Training Program
UT Health San Antonio
University of Minnesota

Emory University Pharmacology

PR & P
University of Michigan Medical School Pharmacology