Enteric Drug Metabolism and Drug-Drug Interactions
Monday April 08, 2019
Eastern Time (ET)
Room W206 B
In Vitro ADMET Laboratories Inc.
There is a great need to develop experimental approaches to define the roles of enteric drug metabolism, uptake and efflux in the fate and biological effects of the orally-administered drugs. This proposed symposium will a review of the current scientific concepts and experimental approaches in the assessment of intestinal drug uptake, metabolism, drug-drug interactions and enterotoxicity. The presentations will include a review of the current understanding of enteric drug metabolizing enzymes and transporters, in vitro and in vivo experimental approaches, as well as PBPK and IVIVE approaches for the translation of preclinical data to clinical outcome.
- University of Washington
A Review of Intestinal Drug Metabolizing Enzymes and Transporters
- In Vitro ADMET Laboratories Inc.
In Vitro Experimental Models for the Evaluation of Intestinal Drug Metabolism, Drug-Drug Interactions, and Drug Toxicity
- Riken Institute
Kinetic Analyses of Interplay of Uptake (OATP2B1), Efflux (P-gp, BCRP) and Metabolizing Enzyme (CYP3A4) in the Intestinal Absorption of Drugs
- Washington State University
Translational Approaches to Address Potential Clinically Significant Enteric Xenobiotic-Drug Interactions