In This Section

Genetic Polymorphisms in Drug Metabolizing Enzymes

Monday April 08, 2019

8:00 am - 10:00 am

Room W206 C
Sponsored by the Division for Toxicology (TOX)
Co-sponsored by the Division for Cardiovascular Pharmacology (CVP)
Co-sponsored by the Division for Drug Discovery and Development (DDD)
Co-sponsored by the Division for Drug Metabolism and Disposition (DMDD)
Co-sponsored by the Division for Pharmacology Education (DPE)

Chair :

Lindsay Henderson
University of Washington

Manish Shah
Albany College of Pharmacy and Health Sciences


Genetic polymorphisms in drug metabolizing enzymes are important contributors to inter-individual variability in drug response and can lead to adverse reactions or therapeutic failure. Understanding polymorphisms in humans responsible for such differences could lead to development of safer medications, specific to an individual’s genetic traits. Despite the intense interest to understand how amino acid variations impact enzyme activity, the structural and functional basis of single nucleotide polymorphisms is limited. The objective of this symposium is to elucidate the impact of polymorphisms on enzyme expression, function, as well as drug binding and activation using structural, biophysical, functional, and computational genomic approaches.

Genetic Variations of the Kinases that Phosphorylate Drugs
Namandjé Bumpus - Johns Hopkins Univ School of Medicine

Comprehensive Functionalization of Variants in Clinically Actionable Pharmacogenes
Allan Rettie - University of Washington

Cytochrome P450 Genetic Polymorphisms: Transporter Interplay and Impact on Drug Interactions
David Rodrigues - Pfizer

Structural and Functional Basis of Single Nucleotide Polymorphisms in Cytochrome P450 2C9
Manish Shah - Albany College of Pharmacy and Health Sciences

Isoform-Dependent Effects of Cytochrome P450 Oxidoreductase Polymorphisms on Drug Metabolism by Cytochrome P450 Enzymes in Dogs
Stephanie Martinez - Washington State University

Last Updated: August 15, 2019
Key Dates
April 6

ASPET Business Meeting and Awards Presentation

April 6-9

ASPET Annual Meeting at EB 2019

Thank you to our Annual Meeting partners:

Amgen
University of Florida
Wake Forest University
Washington State University College of Pharmacy and Pharmaceutical Sciences
University of Wisconsin Molecular and Cellular Pharmacology Training Program
UT Health San Antonio
University of Minnesota

Emory University Pharmacology

PR & P
University of Michigan Medical School Pharmacology
jpet_banner
molpharm_banner
dmd_banner
pharmrev_banner