In This Section

Genetic Polymorphisms in Drug Metabolizing Enzymes

Monday April 08, 2019

8:00 am - 10:00 am Eastern Time (ET)

Room W206 C


Chair :

Lindsay Henderson
University of Washington

Manish Shah
Albany College of Pharmacy and Health Sciences

Genetic polymorphisms in drug metabolizing enzymes are important contributors to inter-individual variability in drug response and can lead to adverse reactions or therapeutic failure. Understanding polymorphisms in humans responsible for such differences could lead to development of safer medications, specific to an individual’s genetic traits. Despite the intense interest to understand how amino acid variations impact enzyme activity, the structural and functional basis of single nucleotide polymorphisms is limited. The objective of this symposium is to elucidate the impact of polymorphisms on enzyme expression, function, as well as drug binding and activation using structural, biophysical, functional, and computational genomic approaches.


Namandjé Bumpus - Johns Hopkins Univ School of Medicine

Genetic Variations of the Kinases that Phosphorylate Drugs

Allan Rettie - University of Washington

Comprehensive Functionalization of Variants in Clinically Actionable Pharmacogenes

David Rodrigues - Pfizer

Cytochrome P450 Genetic Polymorphisms: Transporter Interplay and Impact on Drug Interactions

Manish Shah - Albany College of Pharmacy and Health Sciences

Structural and Functional Basis of Single Nucleotide Polymorphisms in Cytochrome P450 2C9

Stephanie Martinez - Washington State University

Isoform-Dependent Effects of Cytochrome P450 Oxidoreductase Polymorphisms on Drug Metabolism by Cytochrome P450 Enzymes in Dogs

Last Updated: August 15, 2019
Key Dates
April 6

ASPET Business Meeting and Awards Presentation

April 6-9

ASPET Annual Meeting at EB 2019