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Mechanisms of Drug-Induced Liver Injury: From Bedside to Bench and Back

Saturday April 06, 2019

11:00 am - 1:00 pm

Room W206 B
Sponsored by the Division for Toxicology (TOX)
Co-sponsored by the Division for Drug Discovery and Development (DDD)
Co-sponsored by the Division for Drug Metabolism and Disposition (DMDD)
Co-sponsored by the Division for Translational and Clinical Pharmacology (TCP)

Chair :

Neil Kaplowitz
Keck School of Medicine of USC

Xiaochao Ma
University of Pittsburgh

Drug-induced liver injury (DILI) remains one of the major concerns for drug developers, regulators, healthcare providers and patients. Unfortunately, the mechanisms of DILI are largely unknown. This symposium will highlight novel insights into the mechanisms of DILI from the perspectives of metabolomics, genomics, and cell signaling pathways. This session will also discuss the potential applications of novel findings from the preclinical studies of DILI for the management of DILI in the clinic.

Novel Insights into the Role of Cell Signaling Pathways in Drug-Induced Liver Injury
Neil Kaplowitz - Keck School of Medicine of USC

Role of Human Pregnane X Receptor in DILI: Drug Metabolism and Beyond
Xiaochao Ma - University of Pittsburgh

Genetic Associations in Drug-induced Liver Injury
Ann Daly - Institute of Cellular Medicine Newcastle University, UK

Translational Approaches to Develop Targeted Therapies in Liver Diseases
Pranoti Mandrekar - University of Massachusetts Medical School

Impact on Acetaminophen-induced Hepatotoxicity by Long Non-coding RNAs HNF1α-AS1 and HNF4α-AS1 in HepaRG Cells
Liming Chen - University of Connecticut

Lactobacillus rhamnosus GG Supernatant Prevents Acute Alcohol-induced Liver Steatosis and Injury through ER Stress and Autophagy-mediated Signaling Pathways
Lan Zhang - University of Louisville School of Medicine

Last Updated: August 15, 2019
Key Dates
April 6

ASPET Business Meeting and Awards Presentation

April 6-9

ASPET Annual Meeting at EB 2019

Thank you to our Annual Meeting partners:

University of Florida
Wake Forest University
Washington State University College of Pharmacy and Pharmaceutical Sciences
University of Wisconsin Molecular and Cellular Pharmacology Training Program
UT Health San Antonio
University of Minnesota

Emory University Pharmacology

PR & P
University of Michigan Medical School Pharmacology