In This Section

Natural Product-Drug Interactions: Complex Mechanisms and Public Health Impact

Saturday April 06, 2019

2:00 pm - 4:00 pm

Room W206 A
Sponsored by the Division for Drug Metabolism and Disposition (DMDD)
Co-sponsored by the Division for Cardiovascular Pharmacology (CVP)
Co-sponsored by the Division for Drug Discovery and Development (DDD)
Co-sponsored by Division for Toxicology (TOX)

Chair :

Mary Paine
Washington State University

Amy Roe
Procter & Gamble Company


Global sales of botanical and other purported medicinal natural products (NPs) continue to rise, increasing the risk for adverse interactions with co-consumed conventional drugs, potentially leading to suboptimal therapeutic outcomes. Unlike for drug-drug interactions, rigorous guidelines for assessing NP-drug interactions are nonexistent. A multidisciplinary effort involving drug metabolism/pharmacokinetic scientists, clinical pharmacologists, NP chemists, and health informaticists is needed to develop rigorous guidelines for assessing and disseminating the drug interaction liability of NPs. Such guidelines should lead to improved design of future in vitro and clinical NP-drug interaction studies and ultimately, evidenced-based information regarding the optimal management of these complex interactions.

Botanical-Drug Interaction Assessment: A Critical Tier in a Systematic Approach to Botanical Safety
Amy Roe - Procter & Gamble Company

Chinese Herbal Medicines as Objects or Precipitants of Natural Product-Drug Interactions
Chuan Li - Shanghai Institution of Materia Medica, CAS

Sharing is Caring: User-Centered Development of a Natural Product-Drug Interaction Information Portal
Brandon Gufford - Covance Inc.

Differential Effects of Silymarin on Pitavastatin Disposition in Rodent Models of Simple Fatty Liver versus Nonalcoholic Steatohepatitis: a Natural Product-Disease-Drug Interaction
Dan-Dan Tian - Washington State University

'…Not Intended to Diagnose, Treat, Cure or Prevent Any Disease': 25 years of Botanical Dietary Supplement Usage and the Lessons Learned
Bill Gurley - University of Arkansas of Arkansas for Medical Sciences

Last Updated: August 15, 2019
Key Dates
April 6

ASPET Business Meeting and Awards Presentation

April 6-9

ASPET Annual Meeting at EB 2019

Thank you to our Annual Meeting partners:

Amgen
University of Florida
Wake Forest University
Washington State University College of Pharmacy and Pharmaceutical Sciences
University of Wisconsin Molecular and Cellular Pharmacology Training Program
UT Health San Antonio
University of Minnesota

Emory University Pharmacology

PR & P
University of Michigan Medical School Pharmacology
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