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New Roles and Mechanisms of RGS Proteins in Physiology and Disease

Monday April 08, 2019

8:00 am - 10:00 am

Room W205 BC
Sponsored by the Division for Molecular Pharmacology (MP)
Co-sponsored by the Division for Drug Discovery and Development (DDD)

Chair :

Kirill Martemyanov
The Scripps Research Institute

Rory Fisher
University of Iowa Carver College of Medicine


The discovery of Regulators of G Protein Signaling (RGS) proteins, over 20 years ago, fundamentally transformed our views of GPCR signaling. RGS proteins are now well established as GTPase-accelerating proteins promoting inactivation of G proteins to control the magnitude and duration of GPCR-initiated responses. Recent years witnessed tremendous progress in uncovering novel mechanistic details and non-canonical roles of RGS proteins catalyzed by development of relevant genetic mouse models. This symposium explores the latest advances in fundamental mechanisms by which RGS proteins orchestrate cellular signaling, their role in physiology, disease and drug discovery efforts.

Two Birds, One Stone: G protein-dependent and -independent Roles of RGS6
Rory Fisher - University of Iowa Carver College of Medicine

G Protein Selectivity and Human Genetic Variants of RGS Proteins in Health and Disease
Ikuo Masuho - The Scripps Research Institute

Strategies for Targeting RGS Protein Regulation
Benita Sjogren - Purdue University

RGSz1 Modulates Symptoms of Long term Pain and the Actions of Opioid Analgesics
Venetia Zachariou - Icahn School of Medicine at Mount Sinai

RGS Proteins as Therapeutic Targets in Asthma
Kirk Druey - NIAID/NIH

Characterizing a Novel RGS14:MyosinV/VI Interaction in Brain
Carolina Montanez-Miranda - Emory University

Loss of RGS Control at Gαo Reveals a Balance Between Nociceptin and Mu-opioid Receptor Systems
Ram Kandasamy - University of Michigan Medical School

Gbeta5-R7 Regulator of G Protein Signaling Complex is a Positive Regulator of Insulin Secretion
Vladlen Slepak - University of Miami Sch. Med.

Differential Impact of RGS6 on GIRK-dependent Muscarinic and Adenosine Receptor Signaling in Mouse Sinoatrial Nodal Cells
Allison Anderson - University of Minnesota

A Novel Interaction between Regulator of G-protein Signaling (RGS10) and STIM2 Identifies New Mechanism for the Regulation of COX-2 in Microglia
Menbere Wendimu - University of Georgia

Last Updated: August 15, 2019
Key Dates
April 6

ASPET Business Meeting and Awards Presentation

April 6-9

ASPET Annual Meeting at EB 2019

Thank you to our Annual Meeting partners:

Amgen
University of Florida
Wake Forest University
Washington State University College of Pharmacy and Pharmaceutical Sciences
University of Wisconsin Molecular and Cellular Pharmacology Training Program
UT Health San Antonio
University of Minnesota

Emory University Pharmacology

PR & P
University of Michigan Medical School Pharmacology
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