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Virtual Pharmacology and Experimental Therapeutics: Near or Distant?

Sunday April 07, 2019

3:00 pm - 5:00 pm

Room W206 C
Sponsored by the Division for Translational and Clinical Pharmacology (TCP)
Co-sponsored by the Division for Behavioral Pharmacology (BEH)
Co-sponsored by the Division for Cardiovascular Pharmacology (CVP)
Co-sponsored by the Division for Drug Discovery and Development (DDD)
Co-sponsored by the Division for Drug Metabolism and Disposition (DMDD)
Co-sponsored by the Division for Molecular Pharmacology (MP)
Co-sponsored by the Division for Pharmacology Education (DPE)

Chair :

C. Anthony Hunt
University of California, San Francisco


Given a plausible mechanism-based explanation of a pharmacological phenomenon, it is now feasible to build a virtual version of that explanation in software. The model mechanism and its generated phenomenon can be incrementally improved to become strongly analogous to actual counterparts. By so doing, we open a door to designing and conducting scientifically useful virtual experiments. The symposium will provide three examples of early stage virtual pharmacology, physiology, and therapeutics; show how the approach and methods can become scientifically and clinically productive; and describe how methods and tools are being adapted from engineering domains to improve transparency and credibility.

A Multi-scale Systems Pharmacology Approach to Virtual Therapeutics: Optimizing Drugs, Regimens and Dosing
Denise Kirschner - University of Michigan Medical School

Systems Pharmacology as a Complex Control Problem: The Role of Simulation-aided Design
Gary An - University of Vermont

Exploring Plausible Virtual Model Mechanisms that Better Explain Acetaminophen Hepatotoxicity
C. Anthony Hunt - University of California, San Francisco

Engineering Scientifically Productive Biological Simulations: Tools and Methods from Systems Safety Engineering to Facilitate Translation
Jon Timmis - University of York

Last Updated: August 15, 2019
Key Dates
April 6

ASPET Business Meeting and Awards Presentation

April 6-9

ASPET Annual Meeting at EB 2019

Thank you to our Annual Meeting partners:

Amgen
University of Florida
Wake Forest University
Washington State University College of Pharmacy and Pharmaceutical Sciences
University of Wisconsin Molecular and Cellular Pharmacology Training Program
UT Health San Antonio
University of Minnesota

Emory University Pharmacology

PR & P
University of Michigan Medical School Pharmacology
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