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New Tools in ADME Prediction: Quantitative Omics, Liquid Biopsies and Modeling

Monday April 06, 2020

2:00 pm - 3:30 pm Eastern Time (ET)

Room 15 A


Chair :

Bhagwat Prasad
University of Washington

Andrew Rowland
Flinders University

Characterization of variability in drug disposition is important for clinical study design and individualized drug treatment. As variability in drug disposition cannot be completely described by genetics, characterization of phenotypic variability is critical. This has fostered the development of plasma-derived exosomes as liquid biopsy and endogenous biomarkers for the prediction of drug metabolism and transport. Integration of metabolomics and proteomics data into physiologically-based pharmacokinetic models also supports data translational for better prediction of drug disposition. This symposium will provide an update on various non-invasive and in silico approaches to drive the prediction of in vivo drug disposition.


Andrew Rowland - Flinders University

Exosomes for Prediction of Interindividual Variability in DMEs: How are they Different from Small Molecule Biomarkers?

Aleksandra Galetin - University of Manchester

Modelling and Simulation to Support Qualification of Endogenous Transporter Biomarkers

Emi Kimoto - Pfizer

Utility of Drug Transporter Proteomics to Drive Translational ADME: Modeling of Transporter-mediated Disposition in Non-alcoholic Steatohepatitis (NASH)

Sara Shum - University of Washington

Predicting Renal Clearance of Morphine and Morphine-6-glucuronide using the "Organ-on-a-Chip" Technology and Physiologically-based Pharmacokinetic Modeling

Last Updated: December 10, 2020
Key Dates
March 6

Housing discounts end

March 13

Advance Registration Ends

April 3-4

GPCR Colloquium (separate ticket required)

April 4

ASPET Business Meeting and Awards Presentation

April 4-7

ASPET Annual Meeting at EB 2020

Thank you to our Annual Meeting partners:

University of Kentucky
Icahn School
University of Georgia
University of Minnesota
WSU Pharm-Pharm Sciences Unit
PR & P