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Targeting Autophagy in Cancer

Saturday April 02, 2022

11:00 am - 12:30 pm Eastern Time (ET)

111 AB

DCP

Chair :

Andrew Thorburn
Univ of Colorado Anschutz Medical Campus

Rushika Perera
University of California San Francisco

Christina Towers
Salk Institute



This session will discuss recent advances in targeting autophagy as a treatment for cancer. Four leading investigators will discuss recent advances in the field that explain how autophagy modulation in cancer can affect anti-tumor immunity, how lysosomes regulate cancer behavior, the development of new autophagy inhibitors that target the lysosome in novel ways, and how cancer cell resistance to autophagy inhibitors can arise and may be circumvented.

Speakers

Eileen White - Rutgers University

Role of Autophagy in Suppressing the Anti-cancer Immune Response

This talk will discuss mechanisms by which the autophagy machinery in tumor cells and host tissues modulates anti-tumor immune responses

Rushika Perera - University of California San Francisco

New Features and Functions of Cancer Lysosomes

This talk will discuss recent advances in understanding how lysosomes in cancer cells affect tumor behavior

Ravi Amaravadi - Univ. of Pennsylvania

Developing Autophagy Inhibitors for Cancer Clinical Trials

This talk will discuss the development of new autophagy inhibitors and their application in clinical trials

Christina Towers - Salk Institute

Mechanisms to Circumvent Autophagy Inhibition in Cancer Cells

This talk will discuss how cancer cells adapt to circumvent autophagy inhibition and how this may be leveraged to better treat cancer and avoid therapy resistance.