In This Section

G Protein Signaling in Regulation of Metabolism and Diabetes

Saturday April 04, 2020

2:00 pm - 4:00 pm

Room 17 A
Co-sponsored by the Division for Behavioral Pharmacology (BEH)
Co-sponsored by the Division for Cardiovascular Pharmacology (CVP)
Co-sponsored by the Division for Drug Discovery and Development (DDD)
Co-sponsored by the Division for Molecular Pharmacology (MP)

Chair :

Adriano Marchese
Medical College of Wisconsin

Vladlen Slepak
University of Miami


G protein-coupled receptors (GPCRs) activate signaling pathways in the pancreas, skeletal muscle, the CNS and other tissues to regulate metabolism. This signaling is important in normal physiology, but its dysregulation can lead to diseases such as diabetes and obesity, which are the major contributing factors to cardiovascular disease. Talks in this session will address recently emerged unique and understudied aspects of G protein signaling in metabolism. The session will provide a unifying theme by which targeting novel aspects of GPCR signaling has the potential to be therapeutically relevant in diabetes and obesity.

The Role of the Gbeta5-R7 RGS Protein Complex in Metabolism and Hormone Secretion
Vladlen Slepak - University of Miami

Beta-cell EP3 and Gαz Signaling and Susceptibility to Diabetes: A Beneficial Adaptation or a Dysfunctional Consequence?
Michelle Kimple - University of Wisconsin

Skeletal Muscle-specific Activation of Gq Signaling in vivo greatly Improves Impaired Glucose Homeostasis
Jurgen Wess - NIDDK, Molecular Signaling Section, Laboratory of Bioorganic Chemistry

Chemogenetic Approaches to Define Metabolic Roles of Short Chain Fatty Acids
Graeme Milligan - University of Glasgow

Identification and Characterization of Dual-Acting Small Molecule Modulators targeting Secretin Receptors
Daniela Dengler - Sanford Burnham Prebys Medical Discovery Institute

Beta-cell-specific Loss of the Inhibitory G protein, Gα, has Sex-dependent Effects on Development and Pathophysiology of Type 1 Diabetes
Darby Peter - UW-Madison

Last Updated: November 8, 2019
Key Dates
March 6

Housing discounts end

March 13

Advance Registration Ends

April 3-4

GPCR Colloquium (separate ticket required)

April 4

ASPET Business Meeting and Awards Presentation

April 4-7

ASPET Annual Meeting at EB 2020

Thank you to our Annual Meeting partners:

Univ_Wisconsin
UT_Health_SanAntonio
University of Kentucky
UM MCP Logo
Icahn School
University of Georgia
University of Minnesota
WSU Pharm-Pharm Sciences Unit
ChemoCentryx
PR & P
jpet_banner
molpharm_banner
dmd_banner
pharmrev_banner