In This Section

Daniel Isom

Current position

Assistant Professor, University of Miami Miller School of Medicine


  • Biochemistry, Case Western Reserve University, 2000
  • Molecular Biophysics, The Johns Hopkins University, 2006

ASPET member since: 2020

Administrative Accomplishments

In my 6 years at the University of Miami I have served on 7 multi-year committees, including the U-LINK Action Team Committee, Bylaw Sub-Committee for Review of Guidelines for Promotion and Tenure, Flow Cytometry Shared Resource Advisory Committee, Classroom Construction Advisory Group, Career Services Steering Committee, Medical Campus Bioinformatics Course Development Committee, and University Research Council. In service to my Pharmacology department, I have chaired two faculty searches, organized our 2021 retreat, and created, maintain, and teach our NextGenMD pharmacokinetics and pharmacodynamics curriculum. I have also made myself available as an annual poster judge for our MSTP program and for the 2021 ASPET meeting.  

Research Areas

I have established an ambitious research program that integrates the molecular and cellular basis of proton sensing, synthetic biology for health/energy and drug discovery, and novel data science for protein structure-function informatics. My team is focused on illuminating the molecular basis of pH sensing and identifying pH‑intelligent ligands/drugs for G protein-coupled receptors (GPCRs). Our unique technologies enable in‑depth pH studies of ambitious numbers of GPCRs with equally ambitious numbers of ligands, lead compounds, known drugs, and libraries of synthetic nanobodies. My lab is also deeply committed to understanding mechanisms by which cells adapt to extracellular acidosis.     

ASPET Activities

  • Molecular Pharmacology, EB2021
    • Poster Judge (2021) 
Other Society Memberships/Activities
  • Biophysical Society
    • Member
  • Protein Society
    • Member
  • American Society for Biochemistry and Molecular Biology
    • Member


Job Postings