Division for Molecular Pharmacology Early Career Awards and Postdoc Competition

Friday April 30, 2021

2:00 pm - 4:00 pm Eastern Time (ET)

View session on the EB Virtual Platform (EB registration required)

MP

Chair :

Kirill Martemyanov
The Scripps Research Institute

Silvio Gutkind
Univ of California, San Diego



This award competition features oral presentations from postdoctoral trainees selected from the submitted abstracts as well as keynote lectures from winners of the ASPET Division for Molecular Pharmacology Early Career Award.

Speakers

Takefumi Kimura - Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases

Gq Signaling in Adipocytes is a Key Regulator of Systemic Glucose and Lipid Homeostasis

Yi-Jye Chern - Stony Brook University

RNF8 Stabilizes MYC via K63-linked Ubiquitination to Promote Metabolic Reprogramming in Triple-negative Breast Cancer

Pedro Torres-Ayuso - National Cancer Institute

TNIK, A Novel Activator of FAK and YAP Signaling, is a Therapeutic Target in Lung Squamous Cell Carcinoma

Qiuyan Chen - Purdue University

Structure of the Rhodopsin–rhodopsin Kinase Complex Defines the Rules of Engagement between G protein-coupled Receptors (GPCRs) and GPCR Kinases

Karen Gregory - Monash University

Molecular Neuropharmacology of Metabotropic Glutamate Receptor 5 Allosteric Modulators

Using rigorous analytical methods we dissect the molecular basis and functional consequences of metabotropic glutamate receptor 5 allosteric modulation. We link these insights to efficacy in preclinical models for psychiatric and neurodegenerative diseases. We aim to improve future rational discovery campaigns for allosteric modulators that optimally fine-tune receptor activity.

Angeline Lyon - Purdue University

A Structure-Based Approach to Understanding Phospholipase C Function

Phospholipase C (PLC) beta and epsilon increase intracellular Ca2+ and PKC activity in response to their direct interactions with G proteins, which target them to membranes and exert allosteric control. Here I describe efforts to tease apart the mechanisms by which G proteins and membranes themselves regulate PLC.

Last Updated: February 8, 2021
Key Dates
 
April 27 – 30, 2021

ASPET Annual Meeting at EB 2021

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